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Exploring the synthetic biology potential of bacteriophages for engineering non-model bacteria

Author

Listed:
  • Eveline-Marie Lammens

    (KU Leuven)

  • Pablo Ivan Nikel

    (Technical University of Denmark)

  • Rob Lavigne

    (KU Leuven)

Abstract

Non-model bacteria like Pseudomonas putida, Lactococcus lactis and other species have unique and versatile metabolisms, offering unique opportunities for Synthetic Biology (SynBio). However, key genome editing and recombineering tools require optimization and large-scale multiplexing to unlock the full SynBio potential of these bacteria. In addition, the limited availability of a set of characterized, species-specific biological parts hampers the construction of reliable genetic circuitry. Mining of currently available, diverse bacteriophages could complete the SynBio toolbox, as they constitute an unexplored treasure trove for fully adapted metabolic modulators and orthogonally-functioning parts, driven by the longstanding co-evolution between phage and host.

Suggested Citation

  • Eveline-Marie Lammens & Pablo Ivan Nikel & Rob Lavigne, 2020. "Exploring the synthetic biology potential of bacteriophages for engineering non-model bacteria," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19124-x
    DOI: 10.1038/s41467-020-19124-x
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    Cited by:

    1. Jan Zrimec & Xiaozhi Fu & Azam Sheikh Muhammad & Christos Skrekas & Vykintas Jauniskis & Nora K. Speicher & Christoph S. Börlin & Vilhelm Verendel & Morteza Haghir Chehreghani & Devdatt Dubhashi & Ver, 2022. "Controlling gene expression with deep generative design of regulatory DNA," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Javier M. Hernández-Sancho & Arnaud Boudigou & Maria V. G. Alván-Vargas & Dekel Freund & Jenny Arnling Bååth & Peter Westh & Kenneth Jensen & Lianet Noda-García & Daniel C. Volke & Pablo I. Nikel, 2024. "A versatile microbial platform as a tunable whole-cell chemical sensor," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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