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A pragmatic randomized controlled trial reports lack of efficacy of hydroxychloroquine on coronavirus disease 2019 viral kinetics

Author

Listed:
  • Magnus Nakrem Lyngbakken

    (Akershus University Hospital
    University of Oslo)

  • Jan-Erik Berdal

    (University of Oslo
    Akershus University Hospital)

  • Arne Eskesen

    (Akershus University Hospital)

  • Dag Kvale

    (University of Oslo
    Oslo University Hospital)

  • Inge Christoffer Olsen

    (Oslo University Hospital)

  • Corina Silvia Rueegg

    (Oslo University Hospital
    Oslo University Hospital)

  • Anbjørg Rangberg

    (Østfold Hospital Trust)

  • Christine Monceyron Jonassen

    (Østfold Hospital Trust)

  • Torbjørn Omland

    (Akershus University Hospital
    University of Oslo)

  • Helge Røsjø

    (University of Oslo
    Akershus University Hospital)

  • Olav Dalgard

    (University of Oslo
    Akershus University Hospital)

Abstract

Here, we randomized 53 patients hospitalized with coronavirus disease 2019 (COVID-19) to hydroxychloroquine therapy (at a dose of 400 mg twice daily for seven days) in addition to standard care or standard care alone (ClinicalTrials.gov Identifier, NCT04316377). All severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive patients 18 years of age or older were eligible for study inclusion if they had moderately severe COVID-19 at admission. Treatment with hydroxychloroquine did not result in a significantly greater rate of decline in SARS-CoV-2 oropharyngeal viral load compared to standard care alone during the first five days. Our results suggest no important antiviral effect of hydroxychloroquine in humans infected with SARS-CoV-2.

Suggested Citation

  • Magnus Nakrem Lyngbakken & Jan-Erik Berdal & Arne Eskesen & Dag Kvale & Inge Christoffer Olsen & Corina Silvia Rueegg & Anbjørg Rangberg & Christine Monceyron Jonassen & Torbjørn Omland & Helge Røsjø , 2020. "A pragmatic randomized controlled trial reports lack of efficacy of hydroxychloroquine on coronavirus disease 2019 viral kinetics," Nature Communications, Nature, vol. 11(1), pages 1-6, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19056-6
    DOI: 10.1038/s41467-020-19056-6
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