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Increased RNA editing in maternal immune activation model of neurodevelopmental disease

Author

Listed:
  • Hadas Tsivion-Visbord

    (Tel-Aviv University)

  • Eli Kopel

    (Bar-Ilan University)

  • Ariel Feiglin

    (Harvard Medical School)

  • Tamar Sofer

    (Harvard University)

  • Ran Barzilay

    (CHOP)

  • Tali Ben-Zur

    (Tel-Aviv University)

  • Orly Yaron

    (Bar-Ilan University)

  • Daniel Offen

    (Tel-Aviv University)

  • Erez Y. Levanon

    (Bar-Ilan University)

Abstract

The etiology of major neurodevelopmental disorders such as schizophrenia and autism is unclear, with evidence supporting a combination of genetic factors and environmental insults, including viral infection during pregnancy. Here we utilized a mouse model of maternal immune activation (MIA) with the viral mimic PolyI:C infection during early gestation. We investigated the transcriptional changes in the brains of mouse fetuses following MIA during the prenatal period, and evaluated the behavioral and biochemical changes in the adult brain. The results reveal an increase in RNA editing levels and dysregulation in brain development-related gene pathways in the fetal brains of MIA mice. These MIA-induced brain editing changes are not observed in adulthood, although MIA-induced behavioral deficits are observed. Taken together, our findings suggest that MIA induces transient dysregulation of RNA editing at a critical time in brain development.

Suggested Citation

  • Hadas Tsivion-Visbord & Eli Kopel & Ariel Feiglin & Tamar Sofer & Ran Barzilay & Tali Ben-Zur & Orly Yaron & Daniel Offen & Erez Y. Levanon, 2020. "Increased RNA editing in maternal immune activation model of neurodevelopmental disease," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19048-6
    DOI: 10.1038/s41467-020-19048-6
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    Cited by:

    1. Miguel Rodriguez de los Santos & Brian H. Kopell & Ariela Buxbaum Grice & Gauri Ganesh & Andy Yang & Pardis Amini & Lora E. Liharska & Eric Vornholt & John F. Fullard & Pengfei Dong & Eric Park & Sara, 2024. "Divergent landscapes of A-to-I editing in postmortem and living human brain," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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