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A high-stringency blueprint of the human proteome

Author

Listed:
  • Subash Adhikari

    (Macquarie University)

  • Edouard C. Nice

    (Macquarie University
    Monash University)

  • Eric W. Deutsch

    (Institute for Systems Biology)

  • Lydie Lane

    (University of Geneva, CMU)

  • Gilbert S. Omenn

    (University of Michigan)

  • Stephen R. Pennington

    (University College Dublin)

  • Young-Ki Paik

    (Yonsei Proteome Research Center)

  • Christopher M. Overall

    (University of British Columbia)

  • Fernando J. Corrales

    (Centro Nacional de Biotecnología-CSIC, Proteored-ISCIII)

  • Ileana M. Cristea

    (Princeton University)

  • Jennifer E. Van Eyk

    (The Smidt Heart Institute)

  • Mathias Uhlén

    (KTH Royal Institute of Technology)

  • Cecilia Lindskog

    (Uppsala University)

  • Daniel W. Chan

    (Johns Hopkins University School of Medicine)

  • Amos Bairoch

    (University of Geneva, CMU)

  • James C. Waddington

    (University College Dublin)

  • Joshua L. Justice

    (Princeton University)

  • Joshua LaBaer

    (Arizona State University)

  • Henry Rodriguez

    (National Cancer Institute, NIH)

  • Fuchu He

    (Beijing Institute of Lifeomics)

  • Markus Kostrzewa

    (Bruker Daltonik GmbH, Microbiology and Diagnostics)

  • Peipei Ping

    (University of California Los Angeles)

  • Rebekah L. Gundry

    (University of Nebraska Medical Center)

  • Peter Stewart

    (Royal Prince Alfred Hospital)

  • Sanjeeva Srivastava

    (Indian Institute of Technology Bombay)

  • Sudhir Srivastava

    (National Institutes of Health)

  • Fabio C. S. Nogueira

    (Federal University of Rio de Janeiro)

  • Gilberto B. Domont

    (Federal University of Rio de Janeiro)

  • Yves Vandenbrouck

    (University of Grenoble Alpes, Inserm, CEA, IRIG-BGE)

  • Maggie P. Y. Lam

    (University of Colorado
    University of Colorado)

  • Sara Wennersten

    (University of Colorado)

  • Juan Antonio Vizcaino

    (European Bioinformatics Institute)

  • Marc Wilkins

    (University of New South Wales)

  • Jochen M. Schwenk

    (KTH Royal Institute of Technology)

  • Emma Lundberg

    (KTH Royal Institute of Technology)

  • Nuno Bandeira

    (University of California, San Diego)

  • Gyorgy Marko-Varga

    (Lund University)

  • Susan T. Weintraub

    (University of Texas Health Science Center San Antonio, UT Health)

  • Charles Pineau

    (University of Rennes, Inserm, EHESP, IREST, UMR_S 1085)

  • Ulrike Kusebauch

    (Institute for Systems Biology)

  • Robert L. Moritz

    (Institute for Systems Biology)

  • Seong Beom Ahn

    (Macquarie University)

  • Magnus Palmblad

    (Leiden University Medical Center)

  • Michael P. Snyder

    (Stanford School of Medicine)

  • Ruedi Aebersold

    (Institute for Systems Biology
    University of Zurich)

  • Mark S. Baker

    (Macquarie University
    Stanford School of Medicine)

Abstract

The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP’s tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.

Suggested Citation

  • Subash Adhikari & Edouard C. Nice & Eric W. Deutsch & Lydie Lane & Gilbert S. Omenn & Stephen R. Pennington & Young-Ki Paik & Christopher M. Overall & Fernando J. Corrales & Ileana M. Cristea & Jennif, 2020. "A high-stringency blueprint of the human proteome," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19045-9
    DOI: 10.1038/s41467-020-19045-9
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    Cited by:

    1. Efren Garcia-Maldonado & Andrew D. Huber & Sergio C. Chai & Stanley Nithianantham & Yongtao Li & Jing Wu & Shyaron Poudel & Darcie J. Miller & Jayaraman Seetharaman & Taosheng Chen, 2024. "Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Nicholas C. Gervais & Rebecca S. Shapiro, 2024. "Discovering the hidden function in fungal genomes," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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