IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v11y2020i1d10.1038_s41467-020-19045-9.html
   My bibliography  Save this article

A high-stringency blueprint of the human proteome

Author

Listed:
  • Subash Adhikari

    (Macquarie University)

  • Edouard C. Nice

    (Macquarie University
    Monash University)

  • Eric W. Deutsch

    (Institute for Systems Biology)

  • Lydie Lane

    (University of Geneva, CMU)

  • Gilbert S. Omenn

    (University of Michigan)

  • Stephen R. Pennington

    (University College Dublin)

  • Young-Ki Paik

    (Yonsei Proteome Research Center)

  • Christopher M. Overall

    (University of British Columbia)

  • Fernando J. Corrales

    (Centro Nacional de Biotecnología-CSIC, Proteored-ISCIII)

  • Ileana M. Cristea

    (Princeton University)

  • Jennifer E. Van Eyk

    (The Smidt Heart Institute)

  • Mathias Uhlén

    (KTH Royal Institute of Technology)

  • Cecilia Lindskog

    (Uppsala University)

  • Daniel W. Chan

    (Johns Hopkins University School of Medicine)

  • Amos Bairoch

    (University of Geneva, CMU)

  • James C. Waddington

    (University College Dublin)

  • Joshua L. Justice

    (Princeton University)

  • Joshua LaBaer

    (Arizona State University)

  • Henry Rodriguez

    (National Cancer Institute, NIH)

  • Fuchu He

    (Beijing Institute of Lifeomics)

  • Markus Kostrzewa

    (Bruker Daltonik GmbH, Microbiology and Diagnostics)

  • Peipei Ping

    (University of California Los Angeles)

  • Rebekah L. Gundry

    (University of Nebraska Medical Center)

  • Peter Stewart

    (Royal Prince Alfred Hospital)

  • Sanjeeva Srivastava

    (Indian Institute of Technology Bombay)

  • Sudhir Srivastava

    (National Institutes of Health)

  • Fabio C. S. Nogueira

    (Federal University of Rio de Janeiro)

  • Gilberto B. Domont

    (Federal University of Rio de Janeiro)

  • Yves Vandenbrouck

    (University of Grenoble Alpes, Inserm, CEA, IRIG-BGE)

  • Maggie P. Y. Lam

    (University of Colorado
    University of Colorado)

  • Sara Wennersten

    (University of Colorado)

  • Juan Antonio Vizcaino

    (European Bioinformatics Institute)

  • Marc Wilkins

    (University of New South Wales)

  • Jochen M. Schwenk

    (KTH Royal Institute of Technology)

  • Emma Lundberg

    (KTH Royal Institute of Technology)

  • Nuno Bandeira

    (University of California, San Diego)

  • Gyorgy Marko-Varga

    (Lund University)

  • Susan T. Weintraub

    (University of Texas Health Science Center San Antonio, UT Health)

  • Charles Pineau

    (University of Rennes, Inserm, EHESP, IREST, UMR_S 1085)

  • Ulrike Kusebauch

    (Institute for Systems Biology)

  • Robert L. Moritz

    (Institute for Systems Biology)

  • Seong Beom Ahn

    (Macquarie University)

  • Magnus Palmblad

    (Leiden University Medical Center)

  • Michael P. Snyder

    (Stanford School of Medicine)

  • Ruedi Aebersold

    (Institute for Systems Biology
    University of Zurich)

  • Mark S. Baker

    (Macquarie University
    Stanford School of Medicine)

Abstract

The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP’s tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.

Suggested Citation

  • Subash Adhikari & Edouard C. Nice & Eric W. Deutsch & Lydie Lane & Gilbert S. Omenn & Stephen R. Pennington & Young-Ki Paik & Christopher M. Overall & Fernando J. Corrales & Ileana M. Cristea & Jennif, 2020. "A high-stringency blueprint of the human proteome," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19045-9
    DOI: 10.1038/s41467-020-19045-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-020-19045-9
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-020-19045-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Efren Garcia-Maldonado & Andrew D. Huber & Sergio C. Chai & Stanley Nithianantham & Yongtao Li & Jing Wu & Shyaron Poudel & Darcie J. Miller & Jayaraman Seetharaman & Taosheng Chen, 2024. "Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19045-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.