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Synthesis and systematic review of reported neonatal SARS-CoV-2 infections

Author

Listed:
  • Roberto Raschetti

    (Paris Saclay University Hospitals, APHP)

  • Alexandre J. Vivanti

    (Paris Saclay University Hospitals, APHP)

  • Christelle Vauloup-Fellous

    (Paris Saclay University Hospitals, APHP)

  • Barbara Loi

    (Paris Saclay University Hospitals, APHP)

  • Alexandra Benachi

    (Paris Saclay University Hospitals, APHP)

  • Daniele De Luca

    (Paris Saclay University Hospitals, APHP
    Paris Saclay University)

Abstract

A number of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections have been reported in neonates. Here, we aim to clarify the transmission route, clinical features and outcomes of these infections. We present a meta-analysis of 176 published cases of neonatal SARS-CoV-2 infections that were defined by at least one positive nasopharyngeal swab and/or the presence of specific IgM. We report that 70% and 30% of infections are due to environmental and vertical transmission, respectively. Our analysis shows that 55% of infected neonates developed COVID-19; the most common symptoms were fever (44%), gastrointestinal (36%), respiratory (52%) and neurological manifestations (18%), and lung imaging was abnormal in 64% of cases. A lack of mother–neonate separation from birth is associated with late SARS-CoV-2 infection (OR 4.94 (95% CI: 1.98–13.08), p = 0.0002; adjusted OR 6.6 (95% CI: 2.6–16), p

Suggested Citation

  • Roberto Raschetti & Alexandre J. Vivanti & Christelle Vauloup-Fellous & Barbara Loi & Alexandra Benachi & Daniele De Luca, 2020. "Synthesis and systematic review of reported neonatal SARS-CoV-2 infections," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18982-9
    DOI: 10.1038/s41467-020-18982-9
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