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Long-range phase synchronization of high-frequency oscillations in human cortex

Author

Listed:
  • G. Arnulfo

    (University of Helsinki
    University of Genoa)

  • S. H. Wang

    (University of Helsinki
    University of Helsinki
    Aalto University)

  • V. Myrov

    (University of Helsinki
    Aalto University)

  • B. Toselli

    (University of Genoa)

  • J. Hirvonen

    (University of Helsinki
    University of Helsinki)

  • M. M. Fato

    (University of Genoa)

  • L. Nobili

    (University of Genoa
    Child Neuropsychiatry Unit, IRCCS Istituto Giannina Gaslini)

  • F. Cardinale

    (Centre of Epilepsy Surgery “C. Munari”, Department of Neuroscience, Niguarda Hospital)

  • A. Rubino

    (Centre of Epilepsy Surgery “C. Munari”, Department of Neuroscience, Niguarda Hospital)

  • A. Zhigalov

    (University of Helsinki
    University of Birmingham)

  • S. Palva

    (University of Helsinki
    University of Glasgow)

  • J. M. Palva

    (University of Helsinki
    University of Helsinki
    Aalto University
    University of Glasgow)

Abstract

Inter-areal synchronization of neuronal oscillations at frequencies below ~100 Hz is a pervasive feature of neuronal activity and is thought to regulate communication in neuronal circuits. In contrast, faster activities and oscillations have been considered to be largely local-circuit-level phenomena without large-scale synchronization between brain regions. We show, using human intracerebral recordings, that 100–400 Hz high-frequency oscillations (HFOs) may be synchronized between widely distributed brain regions. HFO synchronization expresses individual frequency peaks and exhibits reliable connectivity patterns that show stable community structuring. HFO synchronization is also characterized by a laminar profile opposite to that of lower frequencies. Importantly, HFO synchronization is both transiently enhanced and suppressed in separate frequency bands during a response-inhibition task. These findings show that HFO synchronization constitutes a functionally significant form of neuronal spike-timing relationships in brain activity and thus a mesoscopic indication of neuronal communication per se.

Suggested Citation

  • G. Arnulfo & S. H. Wang & V. Myrov & B. Toselli & J. Hirvonen & M. M. Fato & L. Nobili & F. Cardinale & A. Rubino & A. Zhigalov & S. Palva & J. M. Palva, 2020. "Long-range phase synchronization of high-frequency oscillations in human cortex," Nature Communications, Nature, vol. 11(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18975-8
    DOI: 10.1038/s41467-020-18975-8
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    Cited by:

    1. Marco Fuscà & Felix Siebenhühner & Sheng H. Wang & Vladislav Myrov & Gabriele Arnulfo & Lino Nobili & J. Matias Palva & Satu Palva, 2023. "Brain criticality predicts individual levels of inter-areal synchronization in human electrophysiological data," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Kazuki Sakakura & Naoto Kuroda & Masaki Sonoda & Takumi Mitsuhashi & Ethan Firestone & Aimee F. Luat & Neena I. Marupudi & Sandeep Sood & Eishi Asano, 2023. "Developmental atlas of phase-amplitude coupling between physiologic high-frequency oscillations and slow waves," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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