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In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition

Author

Listed:
  • Jennifer A. Mitchel

    (Harvard T.H. Chan School of Public Health)

  • Amit Das

    (Northeastern University)

  • Michael J. O’Sullivan

    (Harvard T.H. Chan School of Public Health)

  • Ian T. Stancil

    (Harvard T.H. Chan School of Public Health)

  • Stephen J. DeCamp

    (Harvard T.H. Chan School of Public Health)

  • Stephan Koehler

    (Harvard T.H. Chan School of Public Health)

  • Oscar H. Ocaña

    (Instituto de Neurociencias (CSIC-UMH))

  • James P. Butler

    (Harvard T.H. Chan School of Public Health)

  • Jeffrey J. Fredberg

    (Harvard T.H. Chan School of Public Health)

  • M. Angela Nieto

    (Instituto de Neurociencias (CSIC-UMH))

  • Dapeng Bi

    (Northeastern University)

  • Jin-Ah Park

    (Harvard T.H. Chan School of Public Health)

Abstract

The epithelial-to-mesenchymal transition (EMT) and the unjamming transition (UJT) each comprises a gateway to cellular migration, plasticity and remodeling, but the extent to which these core programs are distinct, overlapping, or identical has remained undefined. Here, we triggered partial EMT (pEMT) or UJT in differentiated primary human bronchial epithelial cells. After triggering UJT, cell-cell junctions, apico-basal polarity, and barrier function remain intact, cells elongate and align into cooperative migratory packs, and mesenchymal markers of EMT remain unapparent. After triggering pEMT these and other metrics of UJT versus pEMT diverge. A computational model attributes effects of pEMT mainly to diminished junctional tension but attributes those of UJT mainly to augmented cellular propulsion. Through the actions of UJT and pEMT working independently, sequentially, or interactively, those tissues that are subject to development, injury, or disease become endowed with rich mechanisms for cellular migration, plasticity, self-repair, and regeneration.

Suggested Citation

  • Jennifer A. Mitchel & Amit Das & Michael J. O’Sullivan & Ian T. Stancil & Stephen J. DeCamp & Stephan Koehler & Oscar H. Ocaña & James P. Butler & Jeffrey J. Fredberg & M. Angela Nieto & Dapeng Bi & J, 2020. "In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18841-7
    DOI: 10.1038/s41467-020-18841-7
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    Cited by:

    1. Nabila Founounou & Reza Farhadifar & Giovanna M. Collu & Ursula Weber & Michael J. Shelley & Marek Mlodzik, 2021. "Tissue fluidity mediated by adherens junction dynamics promotes planar cell polarity-driven ommatidial rotation," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    2. Mark E. Becker & Laura Martin-Sancho & Lacy M. Simons & Michael D. McRaven & Sumit K. Chanda & Judd F. Hultquist & Thomas J. Hope, 2024. "Live imaging of airway epithelium reveals that mucociliary clearance modulates SARS-CoV-2 spread," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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