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Autophagy facilitates adaptation of budding yeast to respiratory growth by recycling serine for one-carbon metabolism

Author

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  • Alexander I. May

    (Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology
    Tokyo Tech World Research Hub Initiative (WRHI), Institute of Innovative Research, Tokyo Institute of Technology)

  • Mark Prescott

    (Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Clayton campus)

  • Yoshinori Ohsumi

    (Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology)

Abstract

The mechanism and function of autophagy as a highly-conserved bulk degradation pathway are well studied, but the physiological role of autophagy remains poorly understood. We show that autophagy is involved in the adaptation of Saccharomyces cerevisiae to respiratory growth through its recycling of serine. On respiratory media, growth onset, mitochondrial initiator tRNA modification and mitochondrial protein expression are delayed in autophagy defective cells, suggesting that mitochondrial one-carbon metabolism is perturbed in these cells. The supplementation of serine, which is a key one-carbon metabolite, is able to restore mitochondrial protein expression and alleviate delayed respiratory growth. These results indicate that autophagy-derived serine feeds into mitochondrial one-carbon metabolism, supporting the initiation of mitochondrial protein synthesis and allowing rapid adaptation to respiratory growth.

Suggested Citation

  • Alexander I. May & Mark Prescott & Yoshinori Ohsumi, 2020. "Autophagy facilitates adaptation of budding yeast to respiratory growth by recycling serine for one-carbon metabolism," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18805-x
    DOI: 10.1038/s41467-020-18805-x
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    Cited by:

    1. Gang Li & Ziwen Gong & Nawaraj Dulal & Margarita Marroquin-Guzman & Raquel O. Rocha & Michael Richter & Richard A. Wilson, 2023. "A protein kinase coordinates cycles of autophagy and glutaminolysis in invasive hyphae of the fungus Magnaporthe oryzae within rice cells," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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