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Mycobacterium tuberculosis progresses through two phases of latent infection in humans

Author

Listed:
  • Roberto Colangeli

    (Rutgers-New Jersey Medical School)

  • Aditi Gupta

    (Rutgers-New Jersey Medical School)

  • Solange Alves Vinhas

    (Universidade Federal do Espírito Santo (UFES))

  • Uma Deepthi Chippada Venkata

    (Rutgers-New Jersey Medical School)

  • Soyeon Kim

    (Frontier Science Foundation)

  • Courtney Grady

    (Rutgers-New Jersey Medical School)

  • Edward C. Jones-López

    (University of Southern California Los Angeles)

  • Patricia Soteropoulos

    (Rutgers-New Jersey Medical School
    Rutgers-New Jersey Medical School)

  • Moisés Palaci

    (Universidade Federal do Espírito Santo (UFES))

  • Patrícia Marques-Rodrigues

    (Universidade Federal do Espírito Santo (UFES))

  • Padmini Salgame

    (Rutgers-New Jersey Medical School)

  • Jerrold J. Ellner

    (Rutgers-New Jersey Medical School)

  • Reynaldo Dietze

    (Universidade Federal do Espírito Santo (UFES)
    Universidade Nova de Lisboa)

  • David Alland

    (Rutgers-New Jersey Medical School)

Abstract

Little is known about the physiology of latent Mycobacterium tuberculosis infection. We studied the mutational rates of 24 index tuberculosis (TB) cases and their latently infected household contacts who developed active TB up to 5.25 years later, as an indication of bacterial physiological state and possible generation times during latent TB infection in humans. Here we report that the rate of new mutations in the M. tuberculosis genome decline dramatically after two years of latent infection (two-sided p

Suggested Citation

  • Roberto Colangeli & Aditi Gupta & Solange Alves Vinhas & Uma Deepthi Chippada Venkata & Soyeon Kim & Courtney Grady & Edward C. Jones-López & Patricia Soteropoulos & Moisés Palaci & Patrícia Marques-R, 2020. "Mycobacterium tuberculosis progresses through two phases of latent infection in humans," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18699-9
    DOI: 10.1038/s41467-020-18699-9
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