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Satellite glial cells promote regenerative growth in sensory neurons

Author

Listed:
  • Oshri Avraham

    (Washington University School of Medicine)

  • Pan-Yue Deng

    (Washington University School of Medicine)

  • Sara Jones

    (Washington University School of Medicine)

  • Rejji Kuruvilla

    (Johns Hopkins University)

  • Clay F. Semenkovich

    (Washington University School of Medicine
    Washington University School of Medicine)

  • Vitaly A. Klyachko

    (Washington University School of Medicine)

  • Valeria Cavalli

    (Washington University School of Medicine
    Washington University School of Medicine
    Washington University School of Medicine)

Abstract

Peripheral sensory neurons regenerate their axon after nerve injury to enable functional recovery. Intrinsic mechanisms operating in sensory neurons are known to regulate nerve repair, but whether satellite glial cells (SGC), which completely envelop the neuronal soma, contribute to nerve regeneration remains unexplored. Using a single cell RNAseq approach, we reveal that SGC are distinct from Schwann cells and share similarities with astrocytes. Nerve injury elicits changes in the expression of genes related to fatty acid synthesis and peroxisome proliferator-activated receptor (PPARα) signaling. Conditional deletion of fatty acid synthase (Fasn) in SGC impairs axon regeneration. The PPARα agonist fenofibrate rescues the impaired axon regeneration in mice lacking Fasn in SGC. These results indicate that PPARα activity downstream of FASN in SGC contributes to promote axon regeneration in adult peripheral nerves and highlight that the sensory neuron and its surrounding glial coat form a functional unit that orchestrates nerve repair.

Suggested Citation

  • Oshri Avraham & Pan-Yue Deng & Sara Jones & Rejji Kuruvilla & Clay F. Semenkovich & Vitaly A. Klyachko & Valeria Cavalli, 2020. "Satellite glial cells promote regenerative growth in sensory neurons," Nature Communications, Nature, vol. 11(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18642-y
    DOI: 10.1038/s41467-020-18642-y
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    Cited by:

    1. Dalia Halawani & Yiqun Wang & Aarthi Ramakrishnan & Molly Estill & Xijing He & Li Shen & Roland H. Friedel & Hongyan Zou, 2023. "Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    2. Shannon Trombley & Jackson Powell & Pavithran Guttipatti & Andrew Matamoros & Xiaohui Lin & Tristan O’Harrow & Tobias Steinschaden & Leann Miles & Qin Wang & Shuchao Wang & Jingyun Qiu & Qingyang Li &, 2023. "Glia instruct axon regeneration via a ternary modulation of neuronal calcium channels in Drosophila," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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