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Whole genome analysis of water buffalo and global cattle breeds highlights convergent signatures of domestication

Author

Listed:
  • Prasun Dutta

    (University of Edinburgh
    University of Edinburgh)

  • Andrea Talenti

    (University of Edinburgh)

  • Rachel Young

    (University of Edinburgh)

  • Siddharth Jayaraman

    (University of Edinburgh)

  • Rebecca Callaby

    (University of Edinburgh
    Centre for Tropical Livestock Genetics and Health)

  • Santosh Kumar Jadhav

    (Central Research Station)

  • Velu Dhanikachalam

    (Central Research Station)

  • Mayakannan Manikandan

    (Centre for Cellular and Molecular Biology)

  • Bhim B. Biswa

    (Centre for Cellular and Molecular Biology)

  • Wai Y. Low

    (University of Adelaide)

  • John L. Williams

    (University of Adelaide
    Catholic University of the Sacred Heart)

  • Elizabeth Cook

    (International Livestock Research Institute (ILRI)
    Centre for Tropical Livestock Genetics and Health, ILRI Kenya)

  • Phil Toye

    (International Livestock Research Institute (ILRI)
    Centre for Tropical Livestock Genetics and Health, ILRI Kenya)

  • Eileen Wall

    (Scotland’s Rural College (SRUC))

  • Appolinaire Djikeng

    (Centre for Tropical Livestock Genetics and Health
    Centre for Tropical Livestock Genetics and Health, ILRI Kenya)

  • Karen Marshall

    (International Livestock Research Institute (ILRI)
    Centre for Tropical Livestock Genetics and Health, ILRI Kenya)

  • Alan L. Archibald

    (University of Edinburgh)

  • Suresh Gokhale

    (Central Research Station)

  • Satish Kumar

    (Centre for Cellular and Molecular Biology
    Central University of Haryana)

  • David A. Hume

    (Translational Research Institute)

  • James G. D. Prendergast

    (University of Edinburgh
    Centre for Tropical Livestock Genetics and Health)

Abstract

More people globally depend on the water buffalo than any other domesticated species, and as the most closely related domesticated species to cattle they can provide important insights into the shared evolutionary basis of domestication. Here, we sequence the genomes of 79 water buffalo across seven breeds and compare patterns of between breed selective sweeps with those seen for 294 cattle genomes representing 13 global breeds. The genomic regions under selection between cattle breeds significantly overlap regions linked to stature in human genetic studies, with a disproportionate number of these loci also shown to be under selection between water buffalo breeds. Investigation of potential functional variants in the water buffalo genome identifies a rare example of convergent domestication down to the same mutation having independently occurred and been selected for across domesticated species. Cross-species comparisons of recent selective sweeps can consequently help identify and refine important loci linked to domestication.

Suggested Citation

  • Prasun Dutta & Andrea Talenti & Rachel Young & Siddharth Jayaraman & Rebecca Callaby & Santosh Kumar Jadhav & Velu Dhanikachalam & Mayakannan Manikandan & Bhim B. Biswa & Wai Y. Low & John L. Williams, 2020. "Whole genome analysis of water buffalo and global cattle breeds highlights convergent signatures of domestication," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18550-1
    DOI: 10.1038/s41467-020-18550-1
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    Cited by:

    1. A. Talenti & J. Powell & J. D. Hemmink & E. A. J. Cook & D. Wragg & S. Jayaraman & E. Paxton & C. Ezeasor & E. T. Obishakin & E. R. Agusi & A. Tijjani & W. Amanyire & D. Muhanguzi & K. Marshall & A. F, 2022. "A cattle graph genome incorporating global breed diversity," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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