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Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth

Author

Listed:
  • Jan Krivanek

    (Medical University of Vienna
    Masaryk University)

  • Ruslan A. Soldatov

    (Harvard Medical School)

  • Maria Eleni Kastriti

    (Medical University of Vienna
    Karolinska Institutet)

  • Tatiana Chontorotzea

    (Medical University of Vienna)

  • Anna Nele Herdina

    (Karolinska Institutet)

  • Julian Petersen

    (Medical University of Vienna
    Karolinska Institutet)

  • Bara Szarowska

    (Medical University of Vienna)

  • Marie Landova

    (Institute of Animal Physiology and Genetics, CAS)

  • Veronika Kovar Matejova

    (Masaryk University)

  • Lydie Izakovicova Holla

    (Masaryk University)

  • Ulrike Kuchler

    (Medical University of Vienna
    Medical University of Vienna)

  • Ivana Vidovic Zdrilic

    (University of Connecticut Health Center)

  • Anushree Vijaykumar

    (University of Connecticut Health Center)

  • Anamaria Balic

    (University of Helsinki)

  • Pauline Marangoni

    (University of California)

  • Ophir D. Klein

    (University of California
    University of California)

  • Vitor C. M. Neves

    (Centre for Craniofacial and Regenerative Biology, Faculty of Dentistry, Oral & Craniofacial Sciences. King’s College London)

  • Val Yianni

    (Centre for Craniofacial and Regenerative Biology, Faculty of Dentistry, Oral & Craniofacial Sciences. King’s College London)

  • Paul T. Sharpe

    (Centre for Craniofacial and Regenerative Biology, Faculty of Dentistry, Oral & Craniofacial Sciences. King’s College London)

  • Tibor Harkany

    (Medical University of Vienna
    Karolinska Institutet)

  • Brian D. Metscher

    (University of Vienna)

  • Marc Bajénoff

    (Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS UMR)

  • Mina Mina

    (University of Connecticut Health Center)

  • Kaj Fried

    (Karolinska Institutet)

  • Peter V. Kharchenko

    (Harvard Medical School)

  • Igor Adameyko

    (Medical University of Vienna
    Karolinska Institutet
    Medical University of Vienna)

Abstract

Understanding cell types and mechanisms of dental growth is essential for reconstruction and engineering of teeth. Therefore, we investigated cellular composition of growing and non-growing mouse and human teeth. As a result, we report an unappreciated cellular complexity of the continuously-growing mouse incisor, which suggests a coherent model of cell dynamics enabling unarrested growth. This model relies on spatially-restricted stem, progenitor and differentiated populations in the epithelial and mesenchymal compartments underlying the coordinated expansion of two major branches of pulpal cells and diverse epithelial subtypes. Further comparisons of human and mouse teeth yield both parallelisms and differences in tissue heterogeneity and highlight the specifics behind growing and non-growing modes. Despite being similar at a coarse level, mouse and human teeth reveal molecular differences and species-specific cell subtypes suggesting possible evolutionary divergence. Overall, here we provide an atlas of human and mouse teeth with a focus on growth and differentiation.

Suggested Citation

  • Jan Krivanek & Ruslan A. Soldatov & Maria Eleni Kastriti & Tatiana Chontorotzea & Anna Nele Herdina & Julian Petersen & Bara Szarowska & Marie Landova & Veronika Kovar Matejova & Lydie Izakovicova Hol, 2020. "Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth," Nature Communications, Nature, vol. 11(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18512-7
    DOI: 10.1038/s41467-020-18512-7
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    Cited by:

    1. Junjun Jing & Jifan Feng & Yuan Yuan & Tingwei Guo & Jie Lei & Fei Pei & Thach-Vu Ho & Yang Chai, 2022. "Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Sudha Sunil Rajderkar & Kitt Paraiso & Maria Luisa Amaral & Michael Kosicki & Laura E. Cook & Fabrice Darbellay & Cailyn H. Spurrell & Marco Osterwalder & Yiwen Zhu & Han Wu & Sarah Yasmeen Afzal & Ma, 2024. "Dynamic enhancer landscapes in human craniofacial development," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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