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Epidemiological and phylogenetic analysis reveals Flavobacteriaceae as potential ancestral source of tigecycline resistance gene tet(X)

Author

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  • Rong Zhang

    (Second Affiliated Hospital of Zhejiang University, School of Medicine)

  • Ning Dong

    (City University of Hong Kong)

  • Zhangqi Shen

    (China Agricultural University)

  • Yu Zeng

    (Second Affiliated Hospital of Zhejiang University, School of Medicine)

  • Jiauyue Lu

    (Second Affiliated Hospital of Zhejiang University, School of Medicine)

  • Congcong Liu

    (Second Affiliated Hospital of Zhejiang University, School of Medicine)

  • Hongwei Zhou

    (Second Affiliated Hospital of Zhejiang University, School of Medicine)

  • Yanyan Hu

    (Second Affiliated Hospital of Zhejiang University, School of Medicine)

  • Qiaoling Sun

    (Second Affiliated Hospital of Zhejiang University, School of Medicine)

  • Qipeng Cheng

    (City University of Hong Kong
    The Hong Kong Polytechnic University)

  • Lingbing Shu

    (Second Affiliated Hospital of Zhejiang University, School of Medicine)

  • Jiachang Cai

    (Second Affiliated Hospital of Zhejiang University, School of Medicine)

  • Edward Wai-Chi Chan

    (The Hong Kong Polytechnic University)

  • Gongxiang Chen

    (Second Affiliated Hospital of Zhejiang University, School of Medicine)

  • Sheng Chen

    (City University of Hong Kong)

Abstract

Emergence of tigecycline-resistance tet(X) gene orthologues rendered tigecycline ineffective as last-resort antibiotic. To understand the potential origin and transmission mechanisms of these genes, we survey the prevalence of tet(X) and its orthologues in 2997 clinical E. coli and K. pneumoniae isolates collected nationwide in China with results showing very low prevalence on these two types of strains, 0.32% and 0%, respectively. Further surveillance of tet(X) orthologues in 3692 different clinical Gram-negative bacterial strains collected during 1994–2019 in hospitals in Zhejiang province, China reveals 106 (2.7%) tet(X)-bearing strains with Flavobacteriaceae being the dominant (97/376, 25.8%) bacteria. In addition, tet(X)s are found to be predominantly located on the chromosomes of Flavobacteriaceae and share similar GC-content as Flavobacteriaceae. It also further evolves into different orthologues and transmits among different species. Data from this work suggest that Flavobacteriaceae could be the potential ancestral source of the tigecycline resistance gene tet(X).

Suggested Citation

  • Rong Zhang & Ning Dong & Zhangqi Shen & Yu Zeng & Jiauyue Lu & Congcong Liu & Hongwei Zhou & Yanyan Hu & Qiaoling Sun & Qipeng Cheng & Lingbing Shu & Jiachang Cai & Edward Wai-Chi Chan & Gongxiang Che, 2020. "Epidemiological and phylogenetic analysis reveals Flavobacteriaceae as potential ancestral source of tigecycline resistance gene tet(X)," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18475-9
    DOI: 10.1038/s41467-020-18475-9
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