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Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression

Author

Listed:
  • Leonidas S. Lundell

    (University of Copenhagen)

  • Evelyn B. Parr

    (Australian Catholic University)

  • Brooke L. Devlin

    (Australian Catholic University)

  • Lars R. Ingerslev

    (University of Copenhagen)

  • Ali Altıntaş

    (University of Copenhagen)

  • Shogo Sato

    (University of California, Irvine)

  • Paolo Sassone-Corsi

    (University of California, Irvine)

  • Romain Barrès

    (University of Copenhagen)

  • Juleen R. Zierath

    (University of Copenhagen
    Karolinska Institutet)

  • John A. Hawley

    (Australian Catholic University)

Abstract

Time-restricted feeding (TRF) improves metabolism independent of dietary macronutrient composition or energy restriction. To elucidate mechanisms underpinning the effects of short-term TRF, we investigated skeletal muscle and serum metabolic and transcriptomic profiles from 11 men with overweight/obesity after TRF (8 h day−1) and extended feeding (EXF, 15 h day−1) in a randomised cross-over design (trial registration: ACTRN12617000165381). Here we show that muscle core clock gene expression was similar after both interventions. TRF increases the amplitude of oscillating muscle transcripts, but not muscle or serum metabolites. In muscle, TRF induces rhythmicity of several amino acid transporter genes and metabolites. In serum, lipids are the largest class of periodic metabolites, while the majority of phase-shifted metabolites are amino acid related. In conclusion, short-term TRF in overweight men affects the rhythmicity of serum and muscle metabolites and regulates the rhythmicity of genes controlling amino acid transport, without perturbing core clock gene expression.

Suggested Citation

  • Leonidas S. Lundell & Evelyn B. Parr & Brooke L. Devlin & Lars R. Ingerslev & Ali Altıntaş & Shogo Sato & Paolo Sassone-Corsi & Romain Barrès & Juleen R. Zierath & John A. Hawley, 2020. "Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18412-w
    DOI: 10.1038/s41467-020-18412-w
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    Cited by:

    1. Christopher Livelo & Yiming Guo & Farah Abou Daya & Vasanthi Rajasekaran & Shweta Varshney & Hiep D. Le & Stephen Barnes & Satchidananda Panda & Girish C. Melkani, 2023. "Time-restricted feeding promotes muscle function through purine cycle and AMPK signaling in Drosophila obesity models," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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