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DNA methylation study of Huntington’s disease and motor progression in patients and in animal models

Author

Listed:
  • Ake T. Lu

    (University of California, Los Angeles)

  • Pritika Narayan

    (The University of Auckland)

  • Matthew J. Grant

    (The University of Auckland)

  • Peter Langfelder

    (University of California, Los Angeles (UCLA)
    David Geffen School of Medicine at UCLA)

  • Nan Wang

    (University of California, Los Angeles (UCLA)
    David Geffen School of Medicine at UCLA)

  • Seung Kwak

    (CHDI Management/CHDI Foundation)

  • Hilary Wilkinson

    (CHDI Management/CHDI Foundation)

  • Richard Z. Chen

    (CHDI Management/CHDI Foundation)

  • Jian Chen

    (CHDI Management/CHDI Foundation)

  • C. Simon Bawden

    (South Australian Research and Development Institute)

  • Skye R. Rudiger

    (South Australian Research and Development Institute)

  • Marc Ciosi

    (College of Medical, Veterinary and Life Sciences, University of Glasgow)

  • Afroditi Chatzi

    (College of Medical, Veterinary and Life Sciences, University of Glasgow)

  • Alastair Maxwell

    (College of Medical, Veterinary and Life Sciences, University of Glasgow)

  • Timothy A. Hore

    (University of Otago)

  • Jeff Aaronson

    (CHDI Management/CHDI Foundation)

  • Jim Rosinski

    (CHDI Management/CHDI Foundation)

  • Alicia Preiss

    (CHDI Management/CHDI Foundation)

  • Thomas F. Vogt

    (CHDI Management/CHDI Foundation)

  • Giovanni Coppola

    (University of California, Los Angeles (UCLA)
    David Geffen School of Medicine at UCLA)

  • Darren Monckton

    (College of Medical, Veterinary and Life Sciences, University of Glasgow)

  • Russell G. Snell

    (The University of Auckland)

  • X. William Yang

    (University of California, Los Angeles (UCLA)
    David Geffen School of Medicine at UCLA)

  • Steve Horvath

    (University of California, Los Angeles
    University of California, Los Angeles)

Abstract

Although Huntington’s disease (HD) is a well studied Mendelian genetic disorder, less is known about its associated epigenetic changes. Here, we characterize DNA methylation levels in six different tissues from 3 species: a mouse huntingtin (Htt) gene knock-in model, a transgenic HTT sheep model, and humans. Our epigenome-wide association study (EWAS) of human blood reveals that HD mutation status is significantly (p

Suggested Citation

  • Ake T. Lu & Pritika Narayan & Matthew J. Grant & Peter Langfelder & Nan Wang & Seung Kwak & Hilary Wilkinson & Richard Z. Chen & Jian Chen & C. Simon Bawden & Skye R. Rudiger & Marc Ciosi & Afroditi C, 2020. "DNA methylation study of Huntington’s disease and motor progression in patients and in animal models," Nature Communications, Nature, vol. 11(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18255-5
    DOI: 10.1038/s41467-020-18255-5
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