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A programmable epidermal microfluidic valving system for wearable biofluid management and contextual biomarker analysis

Author

Listed:
  • Haisong Lin

    (University of California, Los Angeles)

  • Jiawei Tan

    (University of California, Los Angeles
    University of California, Los Angeles)

  • Jialun Zhu

    (University of California, Los Angeles
    University of California, Los Angeles)

  • Shuyu Lin

    (University of California, Los Angeles)

  • Yichao Zhao

    (University of California, Los Angeles
    University of California, Los Angeles)

  • Wenzhuo Yu

    (University of California, Los Angeles)

  • Hannaneh Hojaiji

    (University of California, Los Angeles)

  • Bo Wang

    (University of California, Los Angeles)

  • Siyang Yang

    (University of California, Los Angeles)

  • Xuanbing Cheng

    (University of California, Los Angeles
    University of California, Los Angeles)

  • Zhaoqing Wang

    (University of California, Los Angeles)

  • Eric Tang

    (University of California, Los Angeles)

  • Christopher Yeung

    (University of California, Los Angeles
    University of California, Los Angeles)

  • Sam Emaminejad

    (University of California, Los Angeles
    University of California, Los Angeles)

Abstract

Active biofluid management is central to the realization of wearable bioanalytical platforms that are poised to autonomously provide frequent, real-time, and accurate measures of biomarkers in epidermally-retrievable biofluids (e.g., sweat). Accordingly, here, a programmable epidermal microfluidic valving system is devised, which is capable of biofluid sampling, routing, and compartmentalization for biomarker analysis. At its core, the system is a network of individually-addressable microheater-controlled thermo-responsive hydrogel valves, augmented with a pressure regulation mechanism to accommodate pressure built-up, when interfacing sweat glands. The active biofluid control achieved by this system is harnessed to create unprecedented wearable bioanalytical capabilities at both the sensor level (decoupling the confounding influence of flow rate variability on sensor response) and the system level (facilitating context-based sensor selection/protection). Through integration with a wireless flexible printed circuit board and seamless bilateral communication with consumer electronics (e.g., smartwatch), contextually-relevant (scheduled/on-demand) on-body biomarker data acquisition/display was achieved.

Suggested Citation

  • Haisong Lin & Jiawei Tan & Jialun Zhu & Shuyu Lin & Yichao Zhao & Wenzhuo Yu & Hannaneh Hojaiji & Bo Wang & Siyang Yang & Xuanbing Cheng & Zhaoqing Wang & Eric Tang & Christopher Yeung & Sam Emamineja, 2020. "A programmable epidermal microfluidic valving system for wearable biofluid management and contextual biomarker analysis," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18238-6
    DOI: 10.1038/s41467-020-18238-6
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    Cited by:

    1. Sitong Li & Rui Zhang & Guanghao Zhang & Luyizheng Shuai & Wang Chang & Xiaoyu Hu & Min Zou & Xiang Zhou & Baigang An & Dong Qian & Zunfeng Liu, 2022. "Microfluidic manipulation by spiral hollow-fibre actuators," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Xiaoxiang Gao & Xiangjun Chen & Hongjie Hu & Xinyu Wang & Wentong Yue & Jing Mu & Zhiyuan Lou & Ruiqi Zhang & Keren Shi & Xue Chen & Muyang Lin & Baiyan Qi & Sai Zhou & Chengchangfeng Lu & Yue Gu & Xi, 2022. "A photoacoustic patch for three-dimensional imaging of hemoglobin and core temperature," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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