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Generation, localization and functions of macrophages during the development of testis

Author

Listed:
  • Emmi Lokka

    (University of Turku
    University of Turku and Åbo Akademi University
    University of Turku)

  • Laura Lintukorpi

    (University of Turku
    University of Turku and Åbo Akademi University)

  • Sheyla Cisneros-Montalvo

    (University of Turku)

  • Juho-Antti Mäkelä

    (University of Turku)

  • Sofia Tyystjärvi

    (University of Turku
    University of Turku and Åbo Akademi University)

  • Venla Ojasalo

    (University of Turku
    University of Turku and Åbo Akademi University)

  • Heidi Gerke

    (University of Turku
    University of Turku and Åbo Akademi University)

  • Jorma Toppari

    (University of Turku
    Turku University Hospital)

  • Pia Rantakari

    (University of Turku
    University of Turku and Åbo Akademi University)

  • Marko Salmi

    (University of Turku
    University of Turku)

Abstract

In the testis, interstitial macrophages are thought to be derived from the yolk sac during fetal development, and later replaced by bone marrow-derived macrophages. By contrast, the peritubular macrophages have been reported to emerge first in the postnatal testis and solely represent descendants of bone marrow-derived monocytes. Here, we define new monocyte and macrophage types in the fetal and postnatal testis using high-dimensional single-cell analyses. Our results show that interstitial macrophages have a dominant contribution from fetal liver-derived precursors, while peritubular macrophages are generated already at birth from embryonic precursors. We find that bone marrow-derived monocytes do not substantially contribute to the replenishment of the testicular macrophage pool even after systemic macrophage depletion. The presence of macrophages prenatally, but not postnatally, is necessary for normal spermatogenesis. Our multifaceted data thus challenge the current paradigms in testicular macrophage biology by delineating their differentiation, homeostasis and functions.

Suggested Citation

  • Emmi Lokka & Laura Lintukorpi & Sheyla Cisneros-Montalvo & Juho-Antti Mäkelä & Sofia Tyystjärvi & Venla Ojasalo & Heidi Gerke & Jorma Toppari & Pia Rantakari & Marko Salmi, 2020. "Generation, localization and functions of macrophages during the development of testis," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18206-0
    DOI: 10.1038/s41467-020-18206-0
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    Cited by:

    1. Xiaowei Gu & Anna Heinrich & Shu-Yun Li & Tony DeFalco, 2023. "Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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