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Cerebrovascular risk factors impact frontoparietal network integrity and executive function in healthy ageing

Author

Listed:
  • Michele Veldsman

    (University of Oxford
    University of Oxford)

  • Xin-You Tai

    (University of Oxford
    Oxford University Hospitals Trust)

  • Thomas Nichols

    (University of Oxford)

  • Steve Smith

    (University of Oxford
    University of Oxford)

  • João Peixoto

    (University of Oxford)

  • Sanjay Manohar

    (University of Oxford
    University of Oxford
    Oxford University Hospitals Trust)

  • Masud Husain

    (University of Oxford
    University of Oxford
    University of Oxford
    Oxford University Hospitals Trust)

Abstract

Healthy cognitive ageing is a societal and public health priority. Cerebrovascular risk factors increase the likelihood of dementia in older people but their impact on cognitive ageing in younger, healthy brains is less clear. The UK Biobank provides cognition and brain imaging measures in the largest population cohort studied to date. Here we show that cognitive abilities of healthy individuals (N = 22,059) in this sample are detrimentally affected by cerebrovascular risk factors. Structural equation modelling revealed that cerebrovascular risk is associated with reduced cerebral grey matter and white matter integrity within a fronto-parietal brain network underlying executive function. Notably, higher systolic blood pressure was associated with worse executive cognitive function in mid-life (44–69 years), but not in late-life (>70 years). During mid-life this association did not occur in the systolic range of 110–140 mmHg. These findings suggest cerebrovascular risk factors impact on brain structure and cognitive function in healthy people.

Suggested Citation

  • Michele Veldsman & Xin-You Tai & Thomas Nichols & Steve Smith & João Peixoto & Sanjay Manohar & Masud Husain, 2020. "Cerebrovascular risk factors impact frontoparietal network integrity and executive function in healthy ageing," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18201-5
    DOI: 10.1038/s41467-020-18201-5
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    Cited by:

    1. Celeste McCracken & Zahra Raisi-Estabragh & Michele Veldsman & Betty Raman & Andrea Dennis & Masud Husain & Thomas E. Nichols & Steffen E. Petersen & Stefan Neubauer, 2022. "Multi-organ imaging demonstrates the heart-brain-liver axis in UK Biobank participants," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Jordi Manuello & Joosung Min & Paul McCarthy & Fidel Alfaro-Almagro & Soojin Lee & Stephen Smith & Lloyd T. Elliott & Anderson M. Winkler & Gwenaëlle Douaud, 2024. "The effects of genetic and modifiable risk factors on brain regions vulnerable to ageing and disease," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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