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Feeding-dependent tentacle development in the sea anemone Nematostella vectensis

Author

Listed:
  • Aissam Ikmi

    (Developmental Biology Unit, European Molecular Biology Laboratory
    Stowers Institute for Medical Research)

  • Petrus J. Steenbergen

    (Developmental Biology Unit, European Molecular Biology Laboratory)

  • Marie Anzo

    (Developmental Biology Unit, European Molecular Biology Laboratory)

  • Mason R. McMullen

    (Stowers Institute for Medical Research
    The University of Kansas Health System)

  • Anniek Stokkermans

    (Developmental Biology Unit, European Molecular Biology Laboratory)

  • Lacey R. Ellington

    (Stowers Institute for Medical Research)

  • Matthew C. Gibson

    (Stowers Institute for Medical Research
    The University of Kansas School of Medicine)

Abstract

In cnidarians, axial patterning is not restricted to embryogenesis but continues throughout a prolonged life history filled with unpredictable environmental changes. How this developmental capacity copes with fluctuations of food availability and whether it recapitulates embryonic mechanisms remain poorly understood. Here we utilize the tentacles of the sea anemone Nematostella vectensis as an experimental paradigm for developmental patterning across distinct life history stages. By analyzing over 1000 growing polyps, we find that tentacle progression is stereotyped and occurs in a feeding-dependent manner. Using a combination of genetic, cellular and molecular approaches, we demonstrate that the crosstalk between Target of Rapamycin (TOR) and Fibroblast growth factor receptor b (Fgfrb) signaling in ring muscles defines tentacle primordia in fed polyps. Interestingly, Fgfrb-dependent polarized growth is observed in polyp but not embryonic tentacle primordia. These findings show an unexpected plasticity of tentacle development, and link post-embryonic body patterning with food availability.

Suggested Citation

  • Aissam Ikmi & Petrus J. Steenbergen & Marie Anzo & Mason R. McMullen & Anniek Stokkermans & Lacey R. Ellington & Matthew C. Gibson, 2020. "Feeding-dependent tentacle development in the sea anemone Nematostella vectensis," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18133-0
    DOI: 10.1038/s41467-020-18133-0
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