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Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure

Author

Listed:
  • Toshihiro Yamaguchi

    (Graduate School of Medicine, The University of Tokyo)

  • Tomokazu S. Sumida

    (Graduate School of Medicine, The University of Tokyo
    Yale School of Medicine)

  • Seitaro Nomura

    (Graduate School of Medicine, The University of Tokyo
    The University of Tokyo)

  • Masahiro Satoh

    (The University of Tokyo
    Chiba University Graduate School of Medicine)

  • Tomoaki Higo

    (Osaka University Graduate School of Medicine)

  • Masamichi Ito

    (Graduate School of Medicine, The University of Tokyo)

  • Toshiyuki Ko

    (Graduate School of Medicine, The University of Tokyo)

  • Kanna Fujita

    (Graduate School of Medicine, The University of Tokyo)

  • Mary E. Sweet

    (University of Colorado)

  • Atsushi Sanbe

    (Iwate Medical University)

  • Kenji Yoshimi

    (Juntendo University Graduate School of Medicine)

  • Ichiro Manabe

    (Graduate School of Medicine, Chiba University)

  • Toshikuni Sasaoka

    (Brain Research Institute, Niigata University)

  • Matthew R. G. Taylor

    (University of Colorado
    University of Colorado)

  • Haruhiro Toko

    (Graduate School of Medicine, The University of Tokyo
    The University of Tokyo)

  • Eiki Takimoto

    (Graduate School of Medicine, The University of Tokyo)

  • Atsuhiko T. Naito

    (Toho University)

  • Issei Komuro

    (Graduate School of Medicine, The University of Tokyo)

Abstract

Pathophysiological roles of cardiac dopamine system remain unknown. Here, we show the role of dopamine D1 receptor (D1R)-expressing cardiomyocytes (CMs) in triggering heart failure-associated ventricular arrhythmia. Comprehensive single-cell resolution analysis identifies the presence of D1R-expressing CMs in both heart failure model mice and in heart failure patients with sustained ventricular tachycardia. Overexpression of D1R in CMs disturbs normal calcium handling while CM-specific deletion of D1R ameliorates heart failure-associated ventricular arrhythmia. Thus, cardiac D1R has the potential to become a therapeutic target for preventing heart failure-associated ventricular arrhythmia.

Suggested Citation

  • Toshihiro Yamaguchi & Tomokazu S. Sumida & Seitaro Nomura & Masahiro Satoh & Tomoaki Higo & Masamichi Ito & Toshiyuki Ko & Kanna Fujita & Mary E. Sweet & Atsushi Sanbe & Kenji Yoshimi & Ichiro Manabe , 2020. "Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure," Nature Communications, Nature, vol. 11(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18128-x
    DOI: 10.1038/s41467-020-18128-x
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