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Steps towards standardized quantification of adult neurogenesis

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  • Xinyu Zhao

    (Waisman Center and University of Wisconsin-Madison
    School of Medicine and Public Health, University of Wisconsin-Madison)

  • Henriette van Praag

    (Brain Institute and Charles E. Schmidt College of Medicine, Florida Atlantic University)

Abstract

New neurons are generated in adult mammals. Adult hippocampal neurogenesis is considered to play an important role in cognition and mental health. The number and properties of newly born neurons are regulatable by a broad range of physiological and pathological conditions. To begin to understand the underlying cellular mechanisms and functional relevance of adult neurogenesis, many studies rely on quantification of adult-born neurons. However, lack of standardized methods to quantify new neurons is impeding research reproducibility across laboratories. Here, we review the importance of stereology, and propose why and how it should be applied to the study of adult neurogenesis.

Suggested Citation

  • Xinyu Zhao & Henriette van Praag, 2020. "Steps towards standardized quantification of adult neurogenesis," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18046-y
    DOI: 10.1038/s41467-020-18046-y
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    Cited by:

    1. Nicola Forte & Serena Boccella & Lea Tunisi & Alba Clara Fernández-Rilo & Roberta Imperatore & Fabio Arturo Iannotti & Maria Risi & Monica Iannotta & Fabiana Piscitelli & Raffaele Capasso & Paolo Giro, 2021. "Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice," Nature Communications, Nature, vol. 12(1), pages 1-20, December.

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