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Preventing and treating PTSD-like memory by trauma contextualization

Author

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  • Alice Shaam Al Abed

    (Physiopathologie de la plasticité neuronale, U1215, INSERM
    Université de Bordeaux
    The Australian National University)

  • Eva-Gunnel Ducourneau

    (Physiopathologie de la plasticité neuronale, U1215, INSERM
    Université de Bordeaux)

  • Chloé Bouarab

    (Physiopathologie de la plasticité neuronale, U1215, INSERM
    Université de Bordeaux
    Ross Hall—Room 7272, 300 Eye (I) Street, NW)

  • Azza Sellami

    (Physiopathologie de la plasticité neuronale, U1215, INSERM
    Université de Bordeaux)

  • Aline Marighetto

    (Physiopathologie de la plasticité neuronale, U1215, INSERM
    Université de Bordeaux)

  • Aline Desmedt

    (Physiopathologie de la plasticité neuronale, U1215, INSERM
    Université de Bordeaux)

Abstract

Post-traumatic stress disorder (PTSD) is characterized by emotional hypermnesia on which preclinical studies focus so far. While this hypermnesia relates to salient traumatic cues, partial amnesia for the traumatic context can also be observed. Here, we show in mice that contextual amnesia is causally involved in PTSD-like memory formation, and that treating the amnesia by re-exposure to all trauma-related cues cures PTSD-like hypermnesia. These findings open a therapeutic perspective based on trauma contextualization and the underlying hippocampal mechanisms.

Suggested Citation

  • Alice Shaam Al Abed & Eva-Gunnel Ducourneau & Chloé Bouarab & Azza Sellami & Aline Marighetto & Aline Desmedt, 2020. "Preventing and treating PTSD-like memory by trauma contextualization," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18002-w
    DOI: 10.1038/s41467-020-18002-w
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