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TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses

Author

Listed:
  • Tatjana Lalic

    (University of Oxford)

  • Aiste Steponenaite

    (University of Kent and University of Greenwich)

  • Liting Wei

    (University of Oxford)

  • Sridhar R. Vasudevan

    (University of Oxford)

  • Alistair Mathie

    (University of Kent and University of Greenwich)

  • Stuart N. Peirson

    (University of Oxford)

  • Gurprit S. Lall

    (University of Kent and University of Greenwich)

  • M. Zameel Cader

    (University of Oxford)

Abstract

The suprachiasmatic nucleus (SCN) is a complex structure dependent upon multiple mechanisms to ensure rhythmic electrical activity that varies between day and night, to determine circadian adaptation and behaviours. SCN neurons are exposed to glutamate from multiple sources including from the retino-hypothalamic tract and from astrocytes. However, the mechanism preventing inappropriate post-synaptic glutamatergic effects is unexplored and unknown. Unexpectedly we discovered that TRESK, a calcium regulated two-pore potassium channel, plays a crucial role in this system. We propose that glutamate activates TRESK through NMDA and AMPA mediated calcium influx and calcineurin activation to then oppose further membrane depolarisation and rising intracellular calcium. Hence, in the absence of TRESK, glutamatergic activity is unregulated leading to membrane depolarisation, increased nocturnal SCN firing, inverted basal calcium levels and impaired sensitivity in light induced phase delays. Our data reveals TRESK plays an essential part in SCN regulatory mechanisms and light induced adaptive behaviours.

Suggested Citation

  • Tatjana Lalic & Aiste Steponenaite & Liting Wei & Sridhar R. Vasudevan & Alistair Mathie & Stuart N. Peirson & Gurprit S. Lall & M. Zameel Cader, 2020. "TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17978-9
    DOI: 10.1038/s41467-020-17978-9
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    Cited by:

    1. Ran Tian & Yaolei Zhang & Hui Kang & Fan Zhang & Zhihong Jin & Jiahao Wang & Peijun Zhang & Xuming Zhou & Janet M. Lanyon & Helen L. Sneath & Lucy Woolford & Guangyi Fan & Songhai Li & Inge Seim, 2024. "Sirenian genomes illuminate the evolution of fully aquatic species within the mammalian superorder afrotheria," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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