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A spike-timing-dependent plasticity rule for dendritic spines

Author

Listed:
  • Sabrina Tazerart

    (University of Montreal
    The CHU Sainte-Justine Research Center)

  • Diana E. Mitchell

    (University of Montreal
    The CHU Sainte-Justine Research Center)

  • Soledad Miranda-Rottmann

    (University of Montreal
    The CHU Sainte-Justine Research Center)

  • Roberto Araya

    (University of Montreal
    The CHU Sainte-Justine Research Center)

Abstract

The structural organization of excitatory inputs supporting spike-timing-dependent plasticity (STDP) remains unknown. We performed a spine STDP protocol using two-photon (2P) glutamate uncaging (pre) paired with postsynaptic spikes (post) in layer 5 pyramidal neurons from juvenile mice. Here we report that pre-post pairings that trigger timing-dependent LTP (t-LTP) produce shrinkage of the activated spine neck and increase in synaptic strength; and post-pre pairings that trigger timing-dependent LTD (t-LTD) decrease synaptic strength without affecting spine shape. Furthermore, the induction of t-LTP with 2P glutamate uncaging in clustered spines ( 40 μm. These results indicate that synaptic cooperativity disrupts t-LTD and extends the temporal window for the induction of t-LTP, leading to STDP only encompassing LTP.

Suggested Citation

  • Sabrina Tazerart & Diana E. Mitchell & Soledad Miranda-Rottmann & Roberto Araya, 2020. "A spike-timing-dependent plasticity rule for dendritic spines," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17861-7
    DOI: 10.1038/s41467-020-17861-7
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