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Cosmc controls B cell homing

Author

Listed:
  • Junwei Zeng

    (Harvard Medical School)

  • Mahmoud Eljalby

    (Harvard Medical School)

  • Rajindra P. Aryal

    (Harvard Medical School)

  • Sylvain Lehoux

    (Harvard Medical School)

  • Kathrin Stavenhagen

    (Harvard Medical School)

  • Matthew R. Kudelka

    (Harvard Medical School
    Emory University)

  • Yingchun Wang

    (Emory University)

  • Jianmei Wang

    (Emory University)

  • Tongzhong Ju

    (Emory University
    U. S. Food and Drug Administration)

  • Ulrich H. Andrian

    (Harvard Medical School
    MIT & Harvard)

  • Richard D. Cummings

    (Harvard Medical School)

Abstract

The molecular mechanisms regulating lymphocyte homing into lymph nodes are only partly understood. Here, we report that B cell-specific deletion of the X-linked gene, Cosmc, and the consequent decrease of protein O-glycosylation, induces developmental blocks of mouse B cells. After transfer into wild-type recipient, Cosmc-null B cells fail to home to lymph nodes as well as non-lymphoid organs. Enzymatic desialylation of wild-type B cells blocks their migration into lymph nodes, indicating a requirement of sialylated O-glycans for proper trafficking. Mechanistically, Cosmc-deficient B cells have normal rolling and firm arrest on high endothelium venules (HEV), thereby attributing their inefficient trafficking to alterations in the subsequent transendothelial migration step. Finally, Cosmc-null B cells have defective chemokine signaling responses. Our results thus demonstrate that Cosmc and its effects on O-glycosylation are important for controlling B cell homing.

Suggested Citation

  • Junwei Zeng & Mahmoud Eljalby & Rajindra P. Aryal & Sylvain Lehoux & Kathrin Stavenhagen & Matthew R. Kudelka & Yingchun Wang & Jianmei Wang & Tongzhong Ju & Ulrich H. Andrian & Richard D. Cummings, 2020. "Cosmc controls B cell homing," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17765-6
    DOI: 10.1038/s41467-020-17765-6
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    Cited by:

    1. Andrés Manuel González-Ramírez & Ana Sofia Grosso & Zhang Yang & Ismael Compañón & Helena Coelho & Yoshiki Narimatsu & Henrik Clausen & Filipa Marcelo & Francisco Corzana & Ramon Hurtado-Guerrero, 2022. "Structural basis for the synthesis of the core 1 structure by C1GalT1," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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