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Aging alters neural activity at event boundaries in the hippocampus and Posterior Medial network

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  • Zachariah M. Reagh

    (Washington University in St. Louis
    UC Davis Center for Neuroscience, University of California
    University of California)

  • Angelique I. Delarazan

    (Washington University in St. Louis
    UC Davis Center for Neuroscience, University of California)

  • Alexander Garber

    (UC Davis Center for Neuroscience, University of California)

  • Charan Ranganath

    (UC Davis Center for Neuroscience, University of California
    University of California)

Abstract

Recent research has highlighted a role for the hippocampus and a Posterior Medial cortical network in signaling event boundaries. However, little is known about whether or how these neural processes change over the course of healthy aging. Here, 546 cognitively normal participants 18–88 years old viewed a short movie while brain activity was measured using fMRI. The hippocampus and regions of the Posterior Medial network show increased activity at event boundaries, but these boundary-evoked responses decrease with age. Boundary-evoked activity in the posterior hippocampus predicts performance on a separate test of memory for stories, suggesting that hippocampal activity during event segmentation may be a broad indicator of individual differences in episodic memory ability. In contrast, boundary-evoked responses in the medial prefrontal cortex and middle temporal gyrus increase across the age range. These findings suggest that aging may alter neural processes for segmenting and remembering continuous real-world experiences.

Suggested Citation

  • Zachariah M. Reagh & Angelique I. Delarazan & Alexander Garber & Charan Ranganath, 2020. "Aging alters neural activity at event boundaries in the hippocampus and Posterior Medial network," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17713-4
    DOI: 10.1038/s41467-020-17713-4
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    Cited by:

    1. Zachariah M. Reagh & Charan Ranganath, 2023. "Flexible reuse of cortico-hippocampal representations during encoding and recall of naturalistic events," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Hongmi Lee & Janice Chen, 2022. "Predicting memory from the network structure of naturalistic events," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Mason McClay & Matthew E. Sachs & David Clewett, 2023. "Dynamic emotional states shape the episodic structure of memory," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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