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A decade of immune-checkpoint inhibitors in cancer therapy

Author

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  • Caroline Robert

    (Gustave Roussy and Paris-Saclay University)

Abstract

Immunotherapy using immune-checkpoint modulators revolutionizes the oncology field far beyond their remarkable clinical efficacy in some patients. It creates radical changes in the evaluation of treatment efficacy and toxicity with a more holistic vision of the patient with cancer.

Suggested Citation

  • Caroline Robert, 2020. "A decade of immune-checkpoint inhibitors in cancer therapy," Nature Communications, Nature, vol. 11(1), pages 1-3, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17670-y
    DOI: 10.1038/s41467-020-17670-y
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    Cited by:

    1. Jianting Long & Xihe Chen & Mian He & Shudan Ou & Yunhe Zhao & Qingjia Yan & Minjun Ma & Jingyu Chen & Xuping Qin & Xiangjun Zhou & Junjun Chu & Yanyan Han, 2024. "HLA-class II restricted TCR targeting human papillomavirus type 18 E7 induces solid tumor remission in mice," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Qianqian Ming & Daniel Antfolk & David A. Price & Anna Manturova & Elliot Medina & Srishti Singh & Charlotte Mason & Timothy H. Tran & Keiran S. M. Smalley & Daisy W. Leung & Vincent C. Luca, 2024. "Structural basis for mouse LAG3 interactions with the MHC class II molecule I-Ab," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    3. Nandini Pal Basak & Kowshik Jaganathan & Biswajit Das & Oliyarasi Muthusamy & Rajashekar M & Ritu Malhotra & Amit Samal & Moumita Nath & Ganesh MS & Amritha Prabha Shankar & Prakash BV & Vijay Pillai , 2024. "Tumor histoculture captures the dynamic interactions between tumor and immune components in response to anti-PD1 in head and neck cancer," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    4. Pooja Middha & Rohit Thummalapalli & Michael J. Betti & Lydia Yao & Zoe Quandt & Karmugi Balaratnam & Cosmin A. Bejan & Eduardo Cardenas & Christina J. Falcon & David M. Faleck & Matthew A. Gubens & S, 2024. "Polygenic risk score for ulcerative colitis predicts immune checkpoint inhibitor-mediated colitis," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    5. Yue Wang & Shi-Kun Zhou & Yan Wang & Zi-Dong Lu & Yue Zhang & Cong-Fei Xu & Jun Wang, 2023. "Engineering tumor-specific gene nanomedicine to recruit and activate T cells for enhanced immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    6. Avishai Maliah & Nadine Santana-Magal & Shivang Parikh & Sagi Gordon & Keren Reshef & Yuval Sade & Aseel Khateeb & Alon Richter & Amit Gutwillig & Roma Parikh & Tamar Golan & Matan Krissi & Manho Na &, 2024. "Crosslinking of Ly6a metabolically reprograms CD8 T cells for cancer immunotherapy," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    7. Caihua Zhang & Kang Li & Hongzhang Zhu & Maosheng Cheng & Shuang Chen & Rongsong Ling & Cheng Wang & Demeng Chen, 2024. "ITGB6 modulates resistance to anti-CD276 therapy in head and neck cancer by promoting PF4+ macrophage infiltration," Nature Communications, Nature, vol. 15(1), pages 1-23, December.

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