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Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages

Author

Listed:
  • Takumi Hirata

    (Keio University School of Medicine
    Hokkaido University Faculty of Medicine)

  • Yasumichi Arai

    (Keio University School of Medicine
    Keio University Global Research Institute)

  • Shinsuke Yuasa

    (Keio University School of Medicine)

  • Yukiko Abe

    (Keio University School of Medicine)

  • Michiyo Takayama

    (Keio University School of Medicine)

  • Takashi Sasaki

    (Keio University School of Medicine)

  • Akira Kunitomi

    (Keio University School of Medicine)

  • Hiroki Inagaki

    (Tokyo Metropolitan Institute of Gerontology)

  • Motoyoshi Endo

    (Kumamoto University
    University of Occupational and Environmental Health)

  • Jun Morinaga

    (Kumamoto University)

  • Kimio Yoshimura

    (Keio University School of Medicine)

  • Tetsuo Adachi

    (Gifu Pharmaceutical University)

  • Yuichi Oike

    (Kumamoto University)

  • Toru Takebayashi

    (Keio University School of Medicine)

  • Hideyuki Okano

    (Keio University School of Medicine
    Keio University Global Research Institute
    Keio University School of Medicine)

  • Nobuyoshi Hirose

    (Keio University School of Medicine)

Abstract

Supercentenarians (those aged ≥110 years) are approaching the current human longevity limit by preventing or surviving major illness. Identifying specific biomarkers conducive to exceptional survival might provide insights into counter-regulatory mechanisms against aging-related disease. Here, we report associations between cardiovascular disease-related biomarkers and survival to the highest ages using a unique dataset of 1,427 oldest individuals from three longitudinal cohort studies, including 36 supercentenarians, 572 semi-supercentenarians (105–109 years), 288 centenarians (100–104 years), and 531 very old people (85–99 years). During follow-up, 1,000 participants (70.1%) died. Overall, N-terminal pro-B-type natriuretic peptide (NT-proBNP), interleukin-6, cystatin C and cholinesterase are associated with all-cause mortality independent of traditional cardiovascular risk factors and plasma albumin. Of these, low NT-proBNP levels are statistically associated with a survival advantage to supercentenarian age. Only low albumin is associated with high mortality across age groups. These findings expand our knowledge on the biology of human longevity.

Suggested Citation

  • Takumi Hirata & Yasumichi Arai & Shinsuke Yuasa & Yukiko Abe & Michiyo Takayama & Takashi Sasaki & Akira Kunitomi & Hiroki Inagaki & Motoyoshi Endo & Jun Morinaga & Kimio Yoshimura & Tetsuo Adachi & Y, 2020. "Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages," Nature Communications, Nature, vol. 11(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17636-0
    DOI: 10.1038/s41467-020-17636-0
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