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Intratumoral generation of photothermal gold nanoparticles through a vectorized biomineralization of ionic gold

Author

Listed:
  • Aaron S. Schwartz-Duval

    (University of Illinois, Urbana-Champaign
    University of Illinois, Urbana-Champaign
    Carle Foundation Hospital)

  • Christian J. Konopka

    (University of Illinois, Urbana-Champaign
    University of Illinois, Urbana-Champaign)

  • Parikshit Moitra

    (University of Maryland Baltimore School of Medicine
    University of Maryland Baltimore School of Medicine
    Interdisciplinary Health Sciences Facility)

  • Enrique A. Daza

    (University of Illinois, Urbana-Champaign
    University of Illinois, Urbana-Champaign
    Carle Foundation Hospital)

  • Indrajit Srivastava

    (University of Illinois, Urbana-Champaign
    University of Illinois, Urbana-Champaign
    Carle Foundation Hospital)

  • Elyse V. Johnson

    (Cytoviva inc.)

  • Taylor L. Kampert

    (University of Illinois, Urbana-Champaign
    University of Illinois, Urbana-Champaign
    Carle Foundation Hospital)

  • Stanley Fayn

    (University of Illinois, Urbana-Champaign
    University of Illinois, Urbana-Champaign)

  • Anand Haran

    (University of Illinois, Urbana-Champaign
    University of Illinois, Urbana-Champaign)

  • Lawrence W. Dobrucki

    (University of Illinois, Urbana-Champaign
    University of Illinois, Urbana-Champaign)

  • Dipanjan Pan

    (University of Illinois, Urbana-Champaign
    University of Illinois, Urbana-Champaign
    Carle Foundation Hospital
    University of Maryland Baltimore School of Medicine)

Abstract

Various cancer cells have been demonstrated to have the capacity to form plasmonic gold nanoparticles when chloroauric acid is introduced to their cellular microenvironment. But their biomedical applications are limited, particularly considering the millimolar concentrations and longer incubation period of ionic gold. Here, we describe a simplistic method of intracellular biomineralization to produce plasmonic gold nanoparticles at micromolar concentrations within 30 min of application utilizing polyethylene glycol as delivery vector for ionic gold. We have characterized this process for intracellular gold nanoparticle formation, which progressively accumulates proteins as the ionic gold clusters migrate to the nucleus. This nano-vectorized application of ionic gold emphasizes its potential biomedical opportunities while reducing the quantity of ionic gold and required incubation time. To demonstrate its biomedical potential, we further induce in-situ biosynthesis of gold nanoparticles within MCF7 tumor mouse xenografts which is followed by its photothermal remediation.

Suggested Citation

  • Aaron S. Schwartz-Duval & Christian J. Konopka & Parikshit Moitra & Enrique A. Daza & Indrajit Srivastava & Elyse V. Johnson & Taylor L. Kampert & Stanley Fayn & Anand Haran & Lawrence W. Dobrucki & D, 2020. "Intratumoral generation of photothermal gold nanoparticles through a vectorized biomineralization of ionic gold," Nature Communications, Nature, vol. 11(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17595-6
    DOI: 10.1038/s41467-020-17595-6
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    Cited by:

    1. Bang Lin Li & Jun Jiang Luo & Hao Lin Zou & Qing-Meng Zhang & Liu-Bin Zhao & Hang Qian & Hong Qun Luo & David Tai Leong & Nian Bing Li, 2022. "Chiral nanocrystals grown from MoS2 nanosheets enable photothermally modulated enantioselective release of antimicrobial drugs," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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