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Optomechanical mass spectrometry

Author

Listed:
  • Marc Sansa

    (Université Grenoble Alpes, CEA, LETI)

  • Martial Defoort

    (Université Grenoble Alpes, CEA, LETI
    Université Grenoble Alpes, CNRS, Grenoble INP, TIMA)

  • Ariel Brenac

    (Université Grenoble Alpes, CEA, CNRS, Grenoble INP, IRIG-Spintec)

  • Maxime Hermouet

    (Université Grenoble Alpes, CEA, LETI)

  • Louise Banniard

    (Université Grenoble Alpes, CEA, LETI)

  • Alexandre Fafin

    (Université Grenoble Alpes, CEA, LETI)

  • Marc Gely

    (Université Grenoble Alpes, CEA, LETI)

  • Christophe Masselon

    (CEA, IRIG, Biologie à Grande Echelle
    Inserm, Unité 1038)

  • Ivan Favero

    (Université de Paris)

  • Guillaume Jourdan

    (Université Grenoble Alpes, CEA, LETI)

  • Sébastien Hentz

    (Université Grenoble Alpes, CEA, LETI)

Abstract

Nanomechanical mass spectrometry has proven to be well suited for the analysis of high mass species such as viruses. Still, the use of one-dimensional devices such as vibrating beams forces a trade-off between analysis time and mass resolution. Complex readout schemes are also required to simultaneously monitor multiple resonance modes, which degrades resolution. These issues restrict nanomechanical MS to specific species. We demonstrate here single-particle mass spectrometry with nano-optomechanical resonators fabricated with a Very Large Scale Integration process. The unique motion sensitivity of optomechanics allows designs that are impervious to particle position, stiffness or shape, opening the way to the analysis of large aspect ratio biological objects of great significance such as viruses with a tail or fibrils. Compared to top-down beam resonators with electrical read-out and state-of-the-art mass resolution, we show a three-fold improvement in capture area with no resolution degradation, despite the use of a single resonance mode.

Suggested Citation

  • Marc Sansa & Martial Defoort & Ariel Brenac & Maxime Hermouet & Louise Banniard & Alexandre Fafin & Marc Gely & Christophe Masselon & Ivan Favero & Guillaume Jourdan & Sébastien Hentz, 2020. "Optomechanical mass spectrometry," Nature Communications, Nature, vol. 11(1), pages 1-7, December.
  • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17592-9
    DOI: 10.1038/s41467-020-17592-9
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    Cited by:

    1. Jacopo M. Ponti & Xuanyi Zhao & Luca Iorio & Tommaso Maggioli & Marco Colangelo & Benyamin Davaji & Raffaele Ardito & Richard V. Craster & Cristian Cassella, 2024. "Localized topological states beyond Fano resonances via counter-propagating wave mode conversion in piezoelectric microelectromechanical devices," Nature Communications, Nature, vol. 15(1), pages 1-7, December.

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