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Chromosome 1q21.2 and additional loci influence risk of spontaneous coronary artery dissection and myocardial infarction

Author

Listed:
  • Jacqueline Saw

    (University of British Columbia)

  • Min-Lee Yang

    (University of Michigan Medical School
    University of Michigan Medical School)

  • Mark Trinder

    (University of British Columbia
    University of British Columbia)

  • Catherine Tcheandjieu

    (VA Palo Alto Health Care System
    Stanford University School of Medicine
    Stanford University School of Medicine)

  • Chang Xu

    (University of Michigan School of Public Health)

  • Andrew Starovoytov

    (University of British Columbia)

  • Isabelle Birt

    (University of Michigan Medical School
    University of Michigan Medical School)

  • Michael R. Mathis

    (University of Michigan)

  • Kristina L. Hunker

    (University of Michigan Medical School
    University of Michigan Medical School)

  • Ellen M. Schmidt

    (University of Michigan School of Public Health)

  • Linda Jackson

    (University of British Columbia)

  • Natalia Fendrikova-Mahlay

    (Heart and Vascular Institute, Cleveland Clinic)

  • Matthew Zawistowski

    (University of Michigan School of Public Health)

  • Chad M. Brummett

    (University of Michigan)

  • Sebastian Zoellner

    (University of Michigan School of Public Health)

  • Alexander Katz

    (University of Michigan Medical School
    University of Michigan Medical School
    National Human Genome Research Institute, National Institutes of Health)

  • Dawn M. Coleman

    (University of Michigan)

  • Kirby Swan

    (University of Michigan Medical School
    University of Michigan Medical School)

  • Christopher J. O’Donnell

    (VA Boston Healthcare System
    Brigham and Women’s Hospital)

  • Xiang Zhou

    (University of Michigan School of Public Health)

  • Jun Z. Li

    (University of Michigan Medical School)

  • Heather L. Gornik

    (Heart and Vascular Institute, Cleveland Clinic)

  • Themistocles L. Assimes

    (VA Palo Alto Health Care System
    Stanford University School of Medicine)

  • James C. Stanley

    (University of Michigan)

  • Liam R. Brunham

    (University of British Columbia
    University of British Columbia)

  • Santhi K. Ganesh

    (University of Michigan Medical School
    University of Michigan Medical School)

Abstract

Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic cause of myocardial infarction (MI), typically in young women. We undertook a genome-wide association study of SCAD (Ncases = 270/Ncontrols = 5,263) and identified and replicated an association of rs12740679 at chromosome 1q21.2 (Pdiscovery+replication = 2.19 × 10−12, OR = 1.8) influencing ADAMTSL4 expression. Meta-analysis of discovery and replication samples identified associations with P

Suggested Citation

  • Jacqueline Saw & Min-Lee Yang & Mark Trinder & Catherine Tcheandjieu & Chang Xu & Andrew Starovoytov & Isabelle Birt & Michael R. Mathis & Kristina L. Hunker & Ellen M. Schmidt & Linda Jackson & Natal, 2020. "Chromosome 1q21.2 and additional loci influence risk of spontaneous coronary artery dissection and myocardial infarction," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17558-x
    DOI: 10.1038/s41467-020-17558-x
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