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Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts

Author

Listed:
  • Milan D. Valyear

    (Concordia University)

  • Iulia Glovaci

    (Concordia University)

  • Audrey Zaari

    (Concordia University)

  • Soraya Lahlou

    (Concordia University)

  • Ivan Trujillo-Pisanty

    (Concordia University)

  • C. Andrew Chapman

    (Concordia University)

  • Nadia Chaudhri

    (Concordia University)

Abstract

Context can influence reactions to environmental cues and this elemental process has implications for substance use disorder. Using an animal model, we show that an alcohol-associated context elevates entry into a fluid port triggered by a conditioned stimulus (CS) that predicted alcohol (CS-triggered alcohol-seeking). This effect persists across multiple sessions and, after it diminishes in extinction, the alcohol context retains the capacity to augment reinstatement. Systemically administered eticlopride and chemogenetic inhibition of ventral tegmental area (VTA) dopamine neurons reduce CS-triggered alcohol-seeking. Chemogenetically silencing VTA dopamine terminals in the nucleus accumbens (NAc) core reduces CS-triggered alcohol-seeking, irrespective of context, whereas silencing VTA dopamine terminals in the NAc shell selectively reduces the elevation of CS-triggered alcohol-seeking in an alcohol context. This dissociation reveals new roles for divergent mesolimbic dopamine circuits in the control of responding to a discrete cue for alcohol and in the amplification of this behaviour in an alcohol context.

Suggested Citation

  • Milan D. Valyear & Iulia Glovaci & Audrey Zaari & Soraya Lahlou & Ivan Trujillo-Pisanty & C. Andrew Chapman & Nadia Chaudhri, 2020. "Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17543-4
    DOI: 10.1038/s41467-020-17543-4
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    Cited by:

    1. Peter Manza & Dardo Tomasi & Ehsan Shokri-Kojori & Rui Zhang & Danielle Kroll & Dana Feldman & Katherine McPherson & Catherine Biesecker & Evan Dennis & Allison Johnson & Kai Yuan & Wen-Tung Wang & Mi, 2023. "Neural circuit selective for fast but not slow dopamine increases in drug reward," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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