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Long-lasting severe immune dysfunction in Ebola virus disease survivors

Author

Listed:
  • Aurélie Wiedemann

    (Université Paris-Est Créteil)

  • Emile Foucat

    (Université Paris-Est Créteil)

  • Hakim Hocini

    (Université Paris-Est Créteil)

  • Cécile Lefebvre

    (Université Paris-Est Créteil)

  • Boris P. Hejblum

    (Vaccine Research Institute (VRI))

  • Mélany Durand

    (Vaccine Research Institute (VRI))

  • Miriam Krüger

    (Vaccine Research Institute (VRI))

  • Alpha Kabinet Keita

    (Montpellier University
    Gamal Nasser University)

  • Ahidjo Ayouba

    (Montpellier University)

  • Stéphane Mély

    (US003 INSERM)

  • José-Carlos Fernandez

    (Université Paris-Est Créteil)

  • Abdoulaye Touré

    (Montpellier University
    Gamal Nasser University
    Institut National de Santé Publique (INSP))

  • Slim Fourati

    (Laboratoire de Virologie)

  • Claire Lévy-Marchal

    (INSERM)

  • Hervé Raoul

    (US003 INSERM)

  • Eric Delaporte

    (Montpellier University)

  • Lamine Koivogui

    (Institut National de Santé Publique (INSP))

  • Rodolphe Thiébaut

    (Vaccine Research Institute (VRI)
    CHU Bordeaux)

  • Christine Lacabaratz

    (Université Paris-Est Créteil)

  • Yves Lévy

    (Université Paris-Est Créteil
    Service Immunologie Clinique)

Abstract

Long-term follow up studies from Ebola virus disease (EVD) survivors (EBOV_S) are lacking. Here, we evaluate immune and gene expression profiles in 35 Guinean EBOV_S from the last West African outbreak, a median of 23 months (IQR [18–25]) after discharge from treatment center. Compared with healthy donors, EBOV_S exhibit increases of blood markers of inflammation, intestinal tissue damage, T cell and B cell activation and a depletion of circulating dendritic cells. All survivors have EBOV-specific IgG antibodies and robust and polyfunctional EBOV-specific memory T-cell responses. Deep sequencing of the genes expressed in blood reveals an enrichment in ‘inflammation’ and ‘antiviral’ pathways. Integrated analyses identify specific immune markers associated with the persistence of clinical symptoms. This study identifies a set of biological and genetic markers that could be used to define a signature of “chronic Ebola virus disease (CEVD)”.

Suggested Citation

  • Aurélie Wiedemann & Emile Foucat & Hakim Hocini & Cécile Lefebvre & Boris P. Hejblum & Mélany Durand & Miriam Krüger & Alpha Kabinet Keita & Ahidjo Ayouba & Stéphane Mély & José-Carlos Fernandez & Abd, 2020. "Long-lasting severe immune dysfunction in Ebola virus disease survivors," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17489-7
    DOI: 10.1038/s41467-020-17489-7
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    Cited by:

    1. Aurélie Wiedemann & Edouard Lhomme & Mélanie Huchon & Emile Foucat & Marion Bérerd-Camara & Lydia Guillaumat & Marcel Yaradouno & Jacqueline Tambalou & Cécile Rodrigues & Alexandre Ribeiro & Abdoul Ha, 2024. "Long-term cellular immunity of vaccines for Zaire Ebola Virus Diseases," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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