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Transplacental transmission of SARS-CoV-2 infection

Author

Listed:
  • Alexandre J. Vivanti

    (Paris Saclay University Hospitals)

  • Christelle Vauloup-Fellous

    (Paris Saclay University Hospitals)

  • Sophie Prevot

    (Paris Saclay University Hospitals, APHP)

  • Veronique Zupan

    (Paris Saclay University Hospitals)

  • Cecile Suffee

    (Paris Saclay University Hospitals)

  • Jeremy Cao

    (Paris Saclay University Hospitals)

  • Alexandra Benachi

    (Paris Saclay University Hospitals)

  • Daniele De Luca

    (Paris Saclay University Hospitals
    Paris Saclay University)

Abstract

SARS-CoV-2 outbreak is the first pandemic of the century. SARS-CoV-2 infection is transmitted through droplets; other transmission routes are hypothesized but not confirmed. So far, it is unclear whether and how SARS-CoV-2 can be transmitted from the mother to the fetus. We demonstrate the transplacental transmission of SARS-CoV-2 in a neonate born to a mother infected in the last trimester and presenting with neurological compromise. The transmission is confirmed by comprehensive virological and pathological investigations. In detail, SARS-CoV-2 causes: (1) maternal viremia, (2) placental infection demonstrated by immunohistochemistry and very high viral load; placental inflammation, as shown by histological examination and immunohistochemistry, and (3) neonatal viremia following placental infection. The neonate is studied clinically, through imaging, and followed up. The neonate presented with neurological manifestations, similar to those described in adult patients.

Suggested Citation

  • Alexandre J. Vivanti & Christelle Vauloup-Fellous & Sophie Prevot & Veronique Zupan & Cecile Suffee & Jeremy Cao & Alexandra Benachi & Daniele De Luca, 2020. "Transplacental transmission of SARS-CoV-2 infection," Nature Communications, Nature, vol. 11(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17436-6
    DOI: 10.1038/s41467-020-17436-6
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    Cited by:

    1. Iman Al Hashmi & Atika Khalaf & Vidya Seshan & Hilal Alsabti & Omar Al Omari & Dalal Yehia & Mohammed Baqer & Jamal Al Khadhuri, 2022. "Maternal and Neonatal Outcomes of Healthy Pregnant Women With COVID-19 Versus High-risk Pregnant Women: A Multi-Center Case-Control Comparison Study," Clinical Nursing Research, , vol. 31(4), pages 702-712, May.

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