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Magnetic field boosted ferroptosis-like cell death and responsive MRI using hybrid vesicles for cancer immunotherapy

Author

Listed:
  • Bo Yu

    (Northwestern University)

  • Bongseo Choi

    (Northwestern University)

  • Weiguo Li

    (Northwestern University
    University of Illinois at Chicago)

  • Dong-Hyun Kim

    (Northwestern University
    University of Illinois at Chicago
    Robert H. Lurie Comprehensive Cancer Center
    McCormick School of Engineering)

Abstract

We report a strategy to boost Fenton reaction triggered by an exogenous circularly polarized magnetic field (MF) to enhance ferroptosis-like cell-death mediated immune response, as well as endow a responsive MRI capability by using a hybrid core-shell vesicles (HCSVs). HCSVs are prepared by loading ascorbic acid (AA) in the core and poly(lactic-co-glycolic acid) shell incorporating iron oxide nanocubes (IONCs). MF triggers the release of AA, resulting in the increase of ferrous ions through the redox reaction between AA and IONCs. A significant tumor suppression is achieved by Fenton reaction-mediated ferroptosis-like cell-death. The oxidative stress induced by the Fenton reaction leads to the exposure of calreticulin on tumor cells, which leads to dendritic cells maturation and the infiltration of cytotoxic T lymphocytes in tumor. Furthermore, the depletion of ferric ions during treatment enables monitoring of the Fe reaction in MRI-R2* signal change. This strategy provides a perspective on ferroptosis-based immunotherapy.

Suggested Citation

  • Bo Yu & Bongseo Choi & Weiguo Li & Dong-Hyun Kim, 2020. "Magnetic field boosted ferroptosis-like cell death and responsive MRI using hybrid vesicles for cancer immunotherapy," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17380-5
    DOI: 10.1038/s41467-020-17380-5
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    Cited by:

    1. Yuxia Liu & Duyang Gao & Yuanyuan He & Jing Ma & Suet Yen Chong & Xinyi Qi & Hui Jun Ting & Zichao Luo & Zhigao Yi & Jingyu Tang & Chao Chang & Jiongwei Wang & Zonghai Sheng & Hairong Zheng & Xiaogang, 2024. "Single-point mutated lanmodulin as a high-performance MRI contrast agent for vascular and kidney imaging," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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