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An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment

Author

Listed:
  • Corine H. GeurtsvanKessel

    (Erasmus MC)

  • Nisreen M. A. Okba

    (Erasmus MC)

  • Zsofia Igloi

    (Erasmus MC)

  • Susanne Bogers

    (Erasmus MC)

  • Carmen W. E. Embregts

    (Erasmus MC)

  • Brigitta M. Laksono

    (Erasmus MC)

  • Lonneke Leijten

    (Erasmus MC)

  • Casper Rokx

    (Section of Infectious Diseaseas, Erasmus MC)

  • Bart Rijnders

    (Section of Infectious Diseaseas, Erasmus MC)

  • Janette Rahamat-Langendoen

    (Radboud University Medical Centre)

  • Johannes P. C. van den Akker

    (Erasmus MC)

  • Jeroen J. A. van Kampen

    (Erasmus MC)

  • Annemiek A. van der Eijk

    (Erasmus MC)

  • Rob S. van Binnendijk

    (Center for Infectious Disease Control, RIVM)

  • Bart Haagmans

    (Erasmus MC)

  • Marion Koopmans

    (Erasmus MC)

Abstract

The world is entering a new era of the COVID-19 pandemic in which there is an increasing call for reliable antibody testing. To support decision making on the deployment of serology for either population screening or diagnostics, we present a detailed comparison of serological COVID-19 assays. We show that among the selected assays there is a wide diversity in assay performance in different scenarios and when correlated to virus neutralizing antibodies. The Wantai ELISA detecting total immunoglobulins against the receptor binding domain of SARS CoV-2, has the best overall characteristics to detect functional antibodies in different stages and severity of disease, including the potential to set a cut-off indicating the presence of protective antibodies. The large variety of available serological assays requires proper assay validation before deciding on deployment of assays for specific applications.

Suggested Citation

  • Corine H. GeurtsvanKessel & Nisreen M. A. Okba & Zsofia Igloi & Susanne Bogers & Carmen W. E. Embregts & Brigitta M. Laksono & Lonneke Leijten & Casper Rokx & Bart Rijnders & Janette Rahamat-Langendoe, 2020. "An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment," Nature Communications, Nature, vol. 11(1), pages 1-5, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17317-y
    DOI: 10.1038/s41467-020-17317-y
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    Cited by:

    1. Yanan Tang & Turun Song & Lu Gao & Saifu Yin & Ming Ma & Yun Tan & Lijuan Wu & Yang Yang & Yanqun Wang & Tao Lin & Feng Li, 2022. "A CRISPR-based ultrasensitive assay detects attomolar concentrations of SARS-CoV-2 antibodies in clinical samples," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    2. Judith A Bouman & Julien Riou & Sebastian Bonhoeffer & Roland R Regoes, 2021. "Estimating the cumulative incidence of SARS-CoV-2 with imperfect serological tests: Exploiting cutoff-free approaches," PLOS Computational Biology, Public Library of Science, vol. 17(2), pages 1-19, February.

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