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Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity

Author

Listed:
  • Amine Toubal

    (Institut Cochin INSERM
    CNRS
    Laboratoire d’Excellence INFLAMEX, Sorbonne Paris Cité)

  • Badr Kiaf

    (Institut Cochin INSERM
    CNRS
    Laboratoire d’Excellence INFLAMEX, Sorbonne Paris Cité)

  • Lucie Beaudoin

    (Institut Cochin INSERM
    CNRS
    Laboratoire d’Excellence INFLAMEX, Sorbonne Paris Cité)

  • Lucie Cagninacci

    (Institut Cochin INSERM
    CNRS
    Laboratoire d’Excellence INFLAMEX, Sorbonne Paris Cité)

  • Moez Rhimi

    (INRA Micalis Institute, Jouy-en-Josas)

  • Blandine Fruchet

    (Institut Cochin INSERM)

  • Jennifer Silva

    (Institut Cochin INSERM)

  • Alexandra J. Corbett

    (University of Melbourne)

  • Yannick Simoni

    (Institut Cochin INSERM
    CNRS
    Laboratoire d’Excellence INFLAMEX, Sorbonne Paris Cité)

  • Olivier Lantz

    (INSERM U932, Institut Curie, PSL University)

  • Jamie Rossjohn

    (Monash University
    Monash University
    Cardiff University, School of Medicine, Heath Park)

  • James McCluskey

    (University of Melbourne)

  • Philippe Lesnik

    (Institute of Cardiometabolism and Nutrition, ICAN, INSERM)

  • Emmanuelle Maguin

    (INRA Micalis Institute, Jouy-en-Josas)

  • Agnès Lehuen

    (Institut Cochin INSERM
    CNRS
    Laboratoire d’Excellence INFLAMEX, Sorbonne Paris Cité)

Abstract

Obesity is associated with low-grade chronic inflammation promoting insulin-resistance and diabetes. Gut microbiota dysbiosis is a consequence as well as a driver of obesity and diabetes. Mucosal-associated invariant T cells (MAIT) are innate-like T cells expressing a semi-invariant T cell receptor restricted to the non-classical MHC class I molecule MR1 presenting bacterial ligands. Here we show that during obesity MAIT cells promote inflammation in both adipose tissue and ileum, leading to insulin resistance and impaired glucose and lipid metabolism. MAIT cells act in adipose tissue by inducing M1 macrophage polarization in an MR1-dependent manner and in the gut by inducing microbiota dysbiosis and loss of gut integrity. Both MAIT cell-induced tissue alterations contribute to metabolic dysfunction. Treatment with MAIT cell inhibitory ligand demonstrates its potential as a strategy against inflammation, dysbiosis and metabolic disorders.

Suggested Citation

  • Amine Toubal & Badr Kiaf & Lucie Beaudoin & Lucie Cagninacci & Moez Rhimi & Blandine Fruchet & Jennifer Silva & Alexandra J. Corbett & Yannick Simoni & Olivier Lantz & Jamie Rossjohn & James McCluskey, 2020. "Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity," Nature Communications, Nature, vol. 11(1), pages 1-20, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17307-0
    DOI: 10.1038/s41467-020-17307-0
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