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Structure of the yeast Swi/Snf complex in a nucleosome free state

Author

Listed:
  • Chengcheng Wang

    (Westlake Institute for Advanced Study
    Westlake University)

  • Zhouyan Guo

    (Westlake Institute for Advanced Study
    Westlake University
    Zhejiang University)

  • Xiechao Zhan

    (Tsinghua University)

  • Fenghua Yang

    (Westlake Institute for Advanced Study
    Westlake University)

  • Mingxuan Wu

    (Westlake University
    Westlake Institute for Advanced Study)

  • Xiaofeng Zhang

    (Westlake Institute for Advanced Study
    Westlake University)

Abstract

SWI/SNF remodelers play a key role in regulating chromatin architecture and gene expression. Here, we report the cryo-EM structure of the Saccharomyces cerevisiae Swi/Snf complex in a nucleosome-free state. The structure consists of a stable triangular base module and a flexible Arp module. The conserved subunits Swi1 and Swi3 form the backbone of the complex and closely interact with other components. Snf6, which is specific for yeast Swi/Snf complex, stabilizes the binding of the ATPase-containing subunit Snf2 to the base module. Comparison of the yeast Swi/Snf and RSC complexes reveals conserved structural features that govern the assembly and function of these two subfamilies of chromatin remodelers. Our findings complement those from recent structures of the yeast and human chromatin remodelers and provide further insights into the assembly and function of the SWI/SNF remodelers.

Suggested Citation

  • Chengcheng Wang & Zhouyan Guo & Xiechao Zhan & Fenghua Yang & Mingxuan Wu & Xiaofeng Zhang, 2020. "Structure of the yeast Swi/Snf complex in a nucleosome free state," Nature Communications, Nature, vol. 11(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17229-x
    DOI: 10.1038/s41467-020-17229-x
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    Cited by:

    1. Vladislav N. Nikolov & Dhara Malavia & Takashi Kubota, 2022. "SWI/SNF and the histone chaperone Rtt106 drive expression of the Pleiotropic Drug Resistance network genes," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Yanli Cheng & Zhongtian Shen & Yaqi Gao & Feilong Chen & Huisha Xu & Qinling Mo & Xinlei Chu & Chang-liang Peng & Takese T. McKenzie & Bridgitte E. Palacios & Jian Hu & Hao Zhou & Jiafu Long, 2022. "Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Fenghua Yang & Tong Bian & Xiechao Zhan & Zhe Chen & Zhihan Xing & Nicolas A. Larsen & Xiaofeng Zhang & Yigong Shi, 2023. "Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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