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Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing

Author

Listed:
  • Sepideh Sadegh

    (Technical University of Munich)

  • Julian Matschinske

    (Technical University of Munich)

  • David B. Blumenthal

    (Technical University of Munich)

  • Gihanna Galindez

    (Technical University of Munich)

  • Tim Kacprowski

    (Technical University of Munich)

  • Markus List

    (Technical University of Munich)

  • Reza Nasirigerdeh

    (Technical University of Munich)

  • Mhaned Oubounyt

    (Technical University of Munich)

  • Andreas Pichlmair

    (Technical University of Munich)

  • Tim Daniel Rose

    (Technical University of Munich)

  • Marisol Salgado-Albarrán

    (Technical University of Munich
    Universidad Autónoma Metropolitana-Cuajimalpa (UAM-C))

  • Julian Späth

    (Technical University of Munich)

  • Alexey Stukalov

    (Technical University of Munich)

  • Nina K. Wenke

    (Technical University of Munich)

  • Kevin Yuan

    (Technical University of Munich)

  • Josch K. Pauling

    (Technical University of Munich)

  • Jan Baumbach

    (Technical University of Munich
    University of Southern Denmark)

Abstract

Coronavirus Disease-2019 (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. Various studies exist about the molecular mechanisms of viral infection. However, such information is spread across many publications and it is very time-consuming to integrate, and exploit. We develop CoVex, an interactive online platform for SARS-CoV-2 host interactome exploration and drug (target) identification. CoVex integrates virus-human protein interactions, human protein-protein interactions, and drug-target interactions. It allows visual exploration of the virus-host interactome and implements systems medicine algorithms for network-based prediction of drug candidates. Thus, CoVex is a resource to understand molecular mechanisms of pathogenicity and to prioritize candidate therapeutics. We investigate recent hypotheses on a systems biology level to explore mechanistic virus life cycle drivers, and to extract drug repurposing candidates. CoVex renders COVID-19 drug research systems-medicine-ready by giving the scientific community direct access to network medicine algorithms. It is available at https://exbio.wzw.tum.de/covex/.

Suggested Citation

  • Sepideh Sadegh & Julian Matschinske & David B. Blumenthal & Gihanna Galindez & Tim Kacprowski & Markus List & Reza Nasirigerdeh & Mhaned Oubounyt & Andreas Pichlmair & Tim Daniel Rose & Marisol Salgad, 2020. "Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17189-2
    DOI: 10.1038/s41467-020-17189-2
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    Cited by:

    1. Sepideh Sadegh & James Skelton & Elisa Anastasi & Judith Bernett & David B. Blumenthal & Gihanna Galindez & Marisol Salgado-Albarrán & Olga Lazareva & Keith Flanagan & Simon Cockell & Cristian Nogales, 2021. "Network medicine for disease module identification and drug repurposing with the NeDRex platform," Nature Communications, Nature, vol. 12(1), pages 1-12, December.

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