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Bile acids drive the newborn’s gut microbiota maturation

Author

Listed:
  • N. Best

    (RWTH University Hospital Aachen, RWTH University
    Maastricht University)

  • U. Rolle-Kampczyk

    (UFZ-Helmholtz Centre for Environmental Research)

  • F. G. Schaap

    (NUTRIM, Maastricht University
    RWTH University Hospital Aachen)

  • M. Basic

    (Institute for Laboratory Animal Science, Hannover Medical School)

  • S. W. M. Olde Damink

    (NUTRIM, Maastricht University
    RWTH University Hospital Aachen)

  • A. Bleich

    (Institute for Laboratory Animal Science, Hannover Medical School)

  • P. H. M. Savelkoul

    (Maastricht University)

  • M. Bergen

    (UFZ-Helmholtz Centre for Environmental Research
    University of Leipzig)

  • J. Penders

    (Maastricht University
    Maastricht University)

  • M. W. Hornef

    (RWTH University Hospital Aachen, RWTH University)

Abstract

Following birth, the neonatal intestine is exposed to maternal and environmental bacteria that successively form a dense and highly dynamic intestinal microbiota. Whereas the effect of exogenous factors has been extensively investigated, endogenous, host-mediated mechanisms have remained largely unexplored. Concomitantly with microbial colonization, the liver undergoes functional transition from a hematopoietic organ to a central organ of metabolic regulation and immune surveillance. The aim of the present study was to analyze the influence of the developing hepatic function and liver metabolism on the early intestinal microbiota. Here, we report on the characterization of the colonization dynamics and liver metabolism in the murine gastrointestinal tract (n = 6–10 per age group) using metabolomic and microbial profiling in combination with multivariate analysis. We observed major age-dependent microbial and metabolic changes and identified bile acids as potent drivers of the early intestinal microbiota maturation. Consistently, oral administration of tauro-cholic acid or β-tauro-murocholic acid to newborn mice (n = 7–14 per group) accelerated postnatal microbiota maturation.

Suggested Citation

  • N. Best & U. Rolle-Kampczyk & F. G. Schaap & M. Basic & S. W. M. Olde Damink & A. Bleich & P. H. M. Savelkoul & M. Bergen & J. Penders & M. W. Hornef, 2020. "Bile acids drive the newborn’s gut microbiota maturation," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17183-8
    DOI: 10.1038/s41467-020-17183-8
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    Cited by:

    1. Bin Zhu & David J. Edwards & Katherine M. Spaine & Laahirie Edupuganti & Andrey Matveyev & Myrna G. Serrano & Gregory A. Buck, 2024. "The association of maternal factors with the neonatal microbiota and health," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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