IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v11y2020i1d10.1038_s41467-020-17097-5.html
   My bibliography  Save this article

The induction and function of the anti-inflammatory fate of TH17 cells

Author

Listed:
  • Hao Xu

    (Yale University)

  • Theodora Agalioti

    (University Medical Center Hamburg-Eppendorf)

  • Jun Zhao

    (Yale University)

  • Babett Steglich

    (University Medical Center Hamburg-Eppendorf)

  • Ramez Wahib

    (University Medical Center Hamburg-Eppendorf)

  • Maria Carolina Amezcua Vesely

    (Yale University)

  • Piotr Bielecki

    (Yale University)

  • Will Bailis

    (University of Pennsylvania
    The Children’s Hospital of Philadelphia)

  • Ruaidhri Jackson

    (Yale University)

  • Daniel Perez

    (University Medical Center Hamburg-Eppendorf)

  • Jakob Izbicki

    (University Medical Center Hamburg-Eppendorf)

  • Paula Licona-Limón

    (Universidad Nacional Autónoma de México)

  • Vesa Kaartinen

    (University of Michigan)

  • Jens Geginat

    (INGM-National Institute of Molecular Genetics “Romeo ed Enrica Invernizzi”
    Università degli studi di Milano)

  • Enric Esplugues

    (Laboratory of Molecular and Cellular Immunology, Principe Felipe Research Center (CIPF))

  • Eva Tolosa

    (University Medical Center Hamburg-Eppendorf)

  • Samuel Huber

    (University Medical Center Hamburg-Eppendorf)

  • Richard A. Flavell

    (Yale University
    Howard Hughes Medical Institute, Yale University School of Medicine)

  • Nicola Gagliani

    (University Medical Center Hamburg-Eppendorf
    University Medical Center Hamburg-Eppendorf
    Solna, Karolinska Institute and University Hospital)

Abstract

TH17 cells exemplify environmental immune adaptation: they can acquire both a pathogenic and an anti-inflammatory fate. However, it is not known whether the anti-inflammatory fate is merely a vestigial trait, or whether it serves to preserve the integrity of the host tissues. Here we show that the capacity of TH17 cells to acquire an anti-inflammatory fate is necessary to sustain immunological tolerance, yet it impairs immune protection against S. aureus. Additionally, we find that TGF-β signalling via Smad3/Smad4 is sufficient for the expression of the anti-inflammatory cytokine, IL-10, in TH17 cells. Our data thus indicate a key function of TH17 cell plasticity in maintaining immune homeostasis, and dissect the molecular mechanisms explaining the functional flexibility of TH17 cells with regard to environmental changes.

Suggested Citation

  • Hao Xu & Theodora Agalioti & Jun Zhao & Babett Steglich & Ramez Wahib & Maria Carolina Amezcua Vesely & Piotr Bielecki & Will Bailis & Ruaidhri Jackson & Daniel Perez & Jakob Izbicki & Paula Licona-Li, 2020. "The induction and function of the anti-inflammatory fate of TH17 cells," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17097-5
    DOI: 10.1038/s41467-020-17097-5
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-020-17097-5
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-020-17097-5?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17097-5. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.