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A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine

Author

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  • Yanjun Guo

    (Division of Preventive Medicine, Brigham and Women’s Hospital
    Harvard Medical School
    Department of Epidemiology, Harvard T.H. Chan School of Public Health)

  • Pamela M. Rist

    (Division of Preventive Medicine, Brigham and Women’s Hospital
    Harvard Medical School
    Department of Epidemiology, Harvard T.H. Chan School of Public Health)

  • Iyas Daghlas

    (Division of Preventive Medicine, Brigham and Women’s Hospital
    Harvard Medical School)

  • Franco Giulianini

    (Division of Preventive Medicine, Brigham and Women’s Hospital)

  • Tobias Kurth

    (Department of Epidemiology, Harvard T.H. Chan School of Public Health
    Institute of Public Health, Charité – Universitätsmedizin Berlin, Charitéplatz 1)

  • Daniel I. Chasman

    (Division of Preventive Medicine, Brigham and Women’s Hospital
    Harvard Medical School)

Abstract

Blood pressure (BP) was inconsistently associated with migraine and the mechanisms of BP-lowering medications in migraine prophylaxis are unknown. Leveraging large-scale summary statistics for migraine (Ncases/Ncontrols = 59,674/316,078) and BP (N = 757,601), we find positive genetic correlations of migraine with diastolic BP (DBP, rg = 0.11, P = 3.56 × 10−06) and systolic BP (SBP, rg = 0.06, P = 0.01), but not pulse pressure (PP, rg = −0.01, P = 0.75). Cross-trait meta-analysis reveals 14 shared loci (P ≤ 5 × 10−08), nine of which replicate (P

Suggested Citation

  • Yanjun Guo & Pamela M. Rist & Iyas Daghlas & Franco Giulianini & Tobias Kurth & Daniel I. Chasman, 2020. "A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17002-0
    DOI: 10.1038/s41467-020-17002-0
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