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Efficient self-assembly of heterometallic triangular necklace with strong antibacterial activity

Author

Listed:
  • Gui-Yuan Wu

    (East China Normal University)

  • Xueliang Shi

    (East China Normal University)

  • Hoa Phan

    (Vinh University)

  • Hang Qu

    (Xiamen University)

  • Yi-Xiong Hu

    (East China Normal University)

  • Guang-Qiang Yin

    (East China Normal University)

  • Xiao-Li Zhao

    (East China Normal University)

  • Xiaopeng Li

    (University of South Florida)

  • Lin Xu

    (East China Normal University)

  • Qilin Yu

    (Nankai University)

  • Hai-Bo Yang

    (East China Normal University)

Abstract

Sophisticated mechanically interlocked molecules (MIMs) with interesting structures, properties and applications have attracted great interest in the field of supramolecular chemistry. We herein report a highly efficient self-assembly of heterometallic triangular necklace 1 containing Cu and Pt metals with strong antibacterial activity. Single-crystal X-ray analysis shows that the finely arranged triangular necklace 1 has two racemic enantiomers in its solid state with intriguing packing motif. The superior antibacterial activity of necklace 1 against both standard and clinically drug-resistant pathogens implies that the presence of Cu(I) center and platinum(II) significantly enhance the bacterium-binding/damaging activity, which is mainly attributed to the highly positively charged nature, the possible synergistic effect of heterometals in the necklace, and the improved stability in culture media. This work clearly discloses the structure-property relationships that the existence of two different metal centers not only facilitates successful construction of heterometallic triangular necklace but also endows it with superior nuclease properties and antibacterial activities.

Suggested Citation

  • Gui-Yuan Wu & Xueliang Shi & Hoa Phan & Hang Qu & Yi-Xiong Hu & Guang-Qiang Yin & Xiao-Li Zhao & Xiaopeng Li & Lin Xu & Qilin Yu & Hai-Bo Yang, 2020. "Efficient self-assembly of heterometallic triangular necklace with strong antibacterial activity," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16940-z
    DOI: 10.1038/s41467-020-16940-z
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    Cited by:

    1. Zhaoming Zhang & Jun Zhao & Zhewen Guo & Hao Zhang & Hui Pan & Qian Wu & Wei You & Wei Yu & Xuzhou Yan, 2022. "Mechanically interlocked networks cross-linked by a molecular necklace," Nature Communications, Nature, vol. 13(1), pages 1-9, December.

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