IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v11y2020i1d10.1038_s41467-020-16915-0.html
   My bibliography  Save this article

Rapid fast-delta decay following prolonged wakefulness marks a phase of wake-inertia in NREM sleep

Author

Listed:
  • Jeffrey Hubbard

    (University of Lausanne)

  • Thomas C. Gent

    (Inselspital University Hospital Bern
    University of Zürich)

  • Marieke M. B. Hoekstra

    (University of Lausanne)

  • Yann Emmenegger

    (University of Lausanne)

  • Valerie Mongrain

    (Université de Montréal)

  • Hans-Peter Landolt

    (University of Zürich
    University of Zürich)

  • Antoine R. Adamantidis

    (Inselspital University Hospital Bern
    University of Bern)

  • Paul Franken

    (University of Lausanne)

Abstract

Sleep-wake driven changes in non-rapid-eye-movement sleep (NREM) sleep (NREMS) EEG delta (δ-)power are widely used as proxy for a sleep homeostatic process. Here, we noted frequency increases in δ-waves in sleep-deprived mice, prompting us to re-evaluate how slow-wave characteristics relate to prior sleep-wake history. We identified two classes of δ-waves; one responding to sleep deprivation with high initial power and fast, discontinuous decay during recovery sleep (δ2) and another unrelated to time-spent-awake with slow, linear decay (δ1). Reanalysis of previously published datasets demonstrates that δ-band heterogeneity after sleep deprivation is also present in human subjects. Similar to sleep deprivation, silencing of centromedial thalamus neurons boosted subsequent δ2-waves, specifically. δ2-dynamics paralleled that of temperature, muscle tone, heart rate, and neuronal ON-/OFF-state lengths, all reverting to characteristic NREMS levels within the first recovery hour. Thus, prolonged waking seems to necessitate a physiological recalibration before typical NREMS can be reinstated.

Suggested Citation

  • Jeffrey Hubbard & Thomas C. Gent & Marieke M. B. Hoekstra & Yann Emmenegger & Valerie Mongrain & Hans-Peter Landolt & Antoine R. Adamantidis & Paul Franken, 2020. "Rapid fast-delta decay following prolonged wakefulness marks a phase of wake-inertia in NREM sleep," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16915-0
    DOI: 10.1038/s41467-020-16915-0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-020-16915-0
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-020-16915-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16915-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.