IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v11y2020i1d10.1038_s41467-020-16893-3.html
   My bibliography  Save this article

Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces

Author

Listed:
  • Adrian Fischer

    (Member of the German Center for Lung Research (DZL))

  • Tim Koopmans

    (Member of the German Center for Lung Research (DZL))

  • Pushkar Ramesh

    (Member of the German Center for Lung Research (DZL))

  • Simon Christ

    (Member of the German Center for Lung Research (DZL))

  • Maximilian Strunz

    (Member of the German Center for Lung Research (DZL))

  • Juliane Wannemacher

    (Member of the German Center for Lung Research (DZL))

  • Michaela Aichler

    (Helmholtz Zentrum München)

  • Annette Feuchtinger

    (Helmholtz Zentrum München)

  • Axel Walch

    (Helmholtz Zentrum München)

  • Meshal Ansari

    (Institute of Computational Biology)

  • Fabian J. Theis

    (Institute of Computational Biology)

  • Kenji Schorpp

    (Institute for Molecular Toxicology and Pharmacology)

  • Kamyar Hadian

    (Institute for Molecular Toxicology and Pharmacology)

  • Philipp-Alexander Neumann

    (Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Department of Surgery)

  • Herbert B. Schiller

    (Member of the German Center for Lung Research (DZL))

  • Yuval Rinkevich

    (Member of the German Center for Lung Research (DZL))

Abstract

Surgical adhesions are bands of scar tissues that abnormally conjoin organ surfaces. Adhesions are a major cause of post-operative and dialysis-related complications, yet their patho-mechanism remains elusive, and prevention agents in clinical trials have thus far failed to achieve efficacy. Here, we uncover the adhesion initiation mechanism by coating beads with human mesothelial cells that normally line organ surfaces, and viewing them under adhesion stimuli. We document expansive membrane protrusions from mesothelia that tether beads with massive accompanying adherence forces. Membrane protrusions precede matrix deposition, and can transmit adhesion stimuli to healthy surfaces. We identify cytoskeletal effectors and calcium signaling as molecular triggers that initiate surgical adhesions. A single, localized dose targeting these early germinal events completely prevented adhesions in a preclinical mouse model, and in human assays. Our findings classifies the adhesion pathology as originating from mesothelial membrane bridges and offer a radically new therapeutic approach to treat adhesions.

Suggested Citation

  • Adrian Fischer & Tim Koopmans & Pushkar Ramesh & Simon Christ & Maximilian Strunz & Juliane Wannemacher & Michaela Aichler & Annette Feuchtinger & Axel Walch & Meshal Ansari & Fabian J. Theis & Kenji , 2020. "Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces," Nature Communications, Nature, vol. 11(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16893-3
    DOI: 10.1038/s41467-020-16893-3
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-020-16893-3
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-020-16893-3?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yi Wang & Yuanhang Xu & Weijie Zhai & Zhinan Zhang & Yuhong Liu & Shujie Cheng & Hongyu Zhang, 2022. "In-situ growth of robust superlubricated nano-skin on electrospun nanofibers for post-operative adhesion prevention," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Joel Zindel & Jonas Mittner & Julia Bayer & Simon L. April-Monn & Andreas Kohler & Ysbrand Nusse & Michel Dosch & Isabel Büchi & Daniel Sanchez-Taltavull & Heather Dawson & Mercedes Gomez de Agüero & , 2021. "Intraperitoneal microbial contamination drives post-surgical peritoneal adhesions by mesothelial EGFR-signaling," Nature Communications, Nature, vol. 12(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16893-3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.