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Transfer functions linking neural calcium to single voxel functional ultrasound signal

Author

Listed:
  • Ali-Kemal Aydin

    (Université de Paris
    Sorbonne Université)

  • William D. Haselden

    (The Pennsylvania State University)

  • Yannick Goulam Houssen

    (Université de Paris)

  • Christophe Pouzat

    (CNRS UMR 8145)

  • Ravi L. Rungta

    (Université de Paris
    Sorbonne Université)

  • Charlie Demené

    (INSERM, CNRS, PSL Research University)

  • Mickael Tanter

    (INSERM, CNRS, PSL Research University)

  • Patrick J. Drew

    (The Pennsylvania State University)

  • Serge Charpak

    (Université de Paris
    Sorbonne Université)

  • Davide Boido

    (Université de Paris
    Commissariat à l’Energie Atomique-Saclay Center)

Abstract

Functional ultrasound imaging (fUS) is an emerging technique that detects changes of cerebral blood volume triggered by brain activation. Here, we investigate the extent to which fUS faithfully reports local neuronal activation by combining fUS and two-photon microscopy (2PM) in a co-registered single voxel brain volume. Using a machine-learning approach, we compute and validate transfer functions between dendritic calcium signals of specific neurons and vascular signals measured at both microscopic (2PM) and mesoscopic (fUS) levels. We find that transfer functions are robust across a wide range of stimulation paradigms and animals, and reveal a second vascular component of neurovascular coupling upon very strong stimulation. We propose that transfer functions can be considered as reliable quantitative reporters to follow neurovascular coupling dynamics.

Suggested Citation

  • Ali-Kemal Aydin & William D. Haselden & Yannick Goulam Houssen & Christophe Pouzat & Ravi L. Rungta & Charlie Demené & Mickael Tanter & Patrick J. Drew & Serge Charpak & Davide Boido, 2020. "Transfer functions linking neural calcium to single voxel functional ultrasound signal," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16774-9
    DOI: 10.1038/s41467-020-16774-9
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    Cited by:

    1. Marine Tournissac & Emmanuelle Chaigneau & Sonia Pfister & Ali-Kemal Aydin & Yannick Goulam Houssen & Philip O’Herron & Jessica Filosa & Mayeul Collot & Anne Joutel & Serge Charpak, 2024. "Neurovascular coupling and CO2 interrogate distinct vascular regulations," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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