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A host–guest approach to combining enzymatic and artificial catalysis for catalyzing biomimetic monooxygenation

Author

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  • Liang Zhao

    (Dalian University of Technology)

  • Junkai Cai

    (Dalian University of Technology)

  • Yanan Li

    (Dalian University of Technology)

  • Jianwei Wei

    (Dalian University of Technology)

  • Chunying Duan

    (Dalian University of Technology
    Dalian University of Technology)

Abstract

Direct transfer of protons and electrons between two tandem reactions is still a great challenge, because overall reaction kinetics is seriously affected by diffusion rate of the proton and electron carriers. We herein report a host–guest supramolecular strategy based on the incorporation of NADH mimics onto the surface of a metal-organic capsule to encapsulate flavin analogues for catalytic biomimetic monooxygenations in conjunction with enzymes. Coupling an artificial catalysis and a natural enzymatic catalysis in the pocket of an enzyme, this host–guest catalyst–enzyme system allows direct proton and electron transport between two catalytic processes via NADH mimics for the monooxygenation of both cyclobutanones and thioethers. This host–guest approach, which involves the direct coupling of abiotic and biotic catalysts via a NADH-containing host, is quite promising compared to normal catalyst–enzyme systems, as it offers the key advantages of supramolecular catalysis in integrated chemical and biological synthetic sequences.

Suggested Citation

  • Liang Zhao & Junkai Cai & Yanan Li & Jianwei Wei & Chunying Duan, 2020. "A host–guest approach to combining enzymatic and artificial catalysis for catalyzing biomimetic monooxygenation," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16714-7
    DOI: 10.1038/s41467-020-16714-7
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