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Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer

Author

Listed:
  • Yingsong Lin

    (Aichi Medical University School of Medicine)

  • Masahiro Nakatochi

    (Nagoya University Graduate School of Medicine
    Nagoya University Graduate School of Medicine)

  • Yasuyuki Hosono

    (Aichi Cancer Center Research Institute)

  • Hidemi Ito

    (Aichi Cancer Center Research Institute
    Nagoya University Graduate School of Medicine)

  • Yoichiro Kamatani

    (RIKEN Center for Integrative Medical Sciences
    Graduate School of Frontier Sciences, The University of Tokyo)

  • Akihito Inoko

    (Aichi Cancer Center Research Institute
    Aichi Medical University School of Medicine)

  • Hiromi Sakamoto

    (National Cancer Center Research Institute)

  • Fumie Kinoshita

    (Nagoya University Hospital)

  • Yumiko Kobayashi

    (Nagoya University Hospital)

  • Hiroshi Ishii

    (Chiba Cancer Center)

  • Masato Ozaka

    (The Cancer Institute Hospital of Japanese Foundation for Cancer Research)

  • Takashi Sasaki

    (The Cancer Institute Hospital of Japanese Foundation for Cancer Research)

  • Masato Matsuyama

    (The Cancer Institute Hospital of Japanese Foundation for Cancer Research)

  • Naoki Sasahira

    (The Cancer Institute Hospital of Japanese Foundation for Cancer Research)

  • Manabu Morimoto

    (Kanagawa Cancer Center)

  • Satoshi Kobayashi

    (Kanagawa Cancer Center)

  • Taito Fukushima

    (Kanagawa Cancer Center)

  • Makoto Ueno

    (Kanagawa Cancer Center)

  • Shinichi Ohkawa

    (Kanagawa Cancer Center)

  • Naoto Egawa

    (Tokyo Metropolitan Hiroo Hospital)

  • Sawako Kuruma

    (Tokyo Metropolitan Komagome Hospital)

  • Mitsuru Mori

    (Hokkaido Chitose College of Rehabilitation)

  • Haruhisa Nakao

    (Aichi Medical University School of Medicine)

  • Yasushi Adachi

    (Sapporo Shirakabadai Hospital)

  • Masumi Okuda

    (Hyogo College of Medicine)

  • Takako Osaki

    (Kyorin University School of Medicine)

  • Shigeru Kamiya

    (Kyorin University School of Medicine)

  • Chaochen Wang

    (Aichi Medical University School of Medicine)

  • Kazuo Hara

    (Aichi Cancer Center Hospital)

  • Yasuhiro Shimizu

    (Aichi Cancer Center Hospital)

  • Tatsuo Miyamoto

    (Research Institute for Radiation Biology and Medicine, Hiroshima University)

  • Yuko Hayashi

    (Aichi Cancer Center Research Institute)

  • Hiromichi Ebi

    (Aichi Cancer Center Research Institute)

  • Tomohiro Kohmoto

    (Tokushima University Graduate School of Medicine
    Aichi Cancer Center Research Institute)

  • Issei Imoto

    (Aichi Cancer Center Research Institute)

  • Yumiko Kasugai

    (Aichi Cancer Center Research Institute
    Nagoya University Graduate School of Medicine)

  • Yoshinori Murakami

    (Institute of Medical Science, The University of Tokyo)

  • Masato Akiyama

    (RIKEN Center for Integrative Medical Sciences
    Graduate School of Medical Sciences, Kyushu University)

  • Kazuyoshi Ishigaki

    (RIKEN Center for Integrative Medical Sciences)

  • Koichi Matsuda

    (Graduate School of Frontier Sciences, The University of Tokyo)

  • Makoto Hirata

    (Institute of Medical Science, The University of Tokyo)

  • Kazuaki Shimada

    (National Cancer Center Hospital)

  • Takuji Okusaka

    (National Cancer Center Hospital)

  • Takahisa Kawaguchi

    (Graduate School of Medicine, Kyoto University)

  • Meiko Takahashi

    (Graduate School of Medicine, Kyoto University)

  • Yoshiyuki Watanabe

    (Kyoto Prefectural University of Medicine)

  • Kiyonori Kuriki

    (School of Food and Nutritional Sciences, University of Shizuoka)

  • Aya Kadota

    (Shiga University of Medical Science)

  • Rieko Okada

    (Nagoya University Graduate School of Medicine)

  • Haruo Mikami

    (Chiba Cancer Center Research Institute)

  • Toshiro Takezaki

    (Kagoshima University Graduate School of Medical and Dental Sciences)

  • Sadao Suzuki

    (Nagoya City University Graduate School of Medical Sciences)

  • Taiki Yamaji

    (National Cancer Center)

  • Motoki Iwasaki

    (National Cancer Center)

  • Norie Sawada

    (National Cancer Center)

  • Atsushi Goto

    (National Cancer Center)

  • Kengo Kinoshita

    (Tohoku University)

  • Nobuo Fuse

    (Tohoku University)

  • Fumiki Katsuoka

    (Tohoku University)

  • Atsushi Shimizu

    (Iwate Medical University)

  • Satoshi S. Nishizuka

    (Iwate Medical University)

  • Kozo Tanno

    (Iwate Medical University
    School of Medicine, Iwate Medicalm University)

  • Ken Suzuki

    (RIKEN Center for Integrative Medical Sciences
    Graduate School of Medicine, The University of Tokyo
    RIKEN Centre for Integrative Medical Sciences
    Osaka University Graduate School of Medicine)

  • Yukinori Okada

    (RIKEN Center for Integrative Medical Sciences
    Osaka University Graduate School of Medicine
    Osaka University)

  • Momoko Horikoshi

    (RIKEN Centre for Integrative Medical Sciences)

  • Toshimasa Yamauchi

    (Graduate School of Medicine, The University of Tokyo)

  • Takashi Kadowaki

    (Graduate School of Medicine, The University of Tokyo)

  • Herbert Yu

    (University of Hawaii Cancer Center)

  • Jun Zhong

    (National Cancer Institute, National Institutes of Health)

  • Laufey T. Amundadottir

    (National Cancer Institute, National Institutes of Health)

  • Yuichiro Doki

    (Graduate School of Medicine, Osaka University)

  • Hideshi Ishii

    (Graduate School of Medicine, Osaka University)

  • Hidetoshi Eguchi

    (Graduate School of Medicine, Osaka University)

  • David Bogumil

    (Keck School of Medicine, University of Southern California)

  • Christopher A. Haiman

    (Keck School of Medicine, University of Southern California
    University of Southern California)

  • Loic Marchand

    (University of Hawaii Cancer Center)

  • Masaki Mori

    (Graduate School of Medical Sciences, Kyushu University)

  • Harvey Risch

    (Yale School of Public Health)

  • Veronica W. Setiawan

    (Keck School of Medicine, University of Southern California
    University of Southern California)

  • Shoichiro Tsugane

    (National Cancer Center)

  • Kenji Wakai

    (Nagoya University Graduate School of Medicine)

  • Teruhiko Yoshida

    (National Cancer Center Research Institute)

  • Fumihiko Matsuda

    (Graduate School of Medicine, Kyoto University)

  • Michiaki Kubo

    (RIKEN Center for Integrative Medical Sciences)

  • Shogo Kikuchi

    (Aichi Medical University School of Medicine)

  • Keitaro Matsuo

    (Aichi Cancer Center Research Institute
    Nagoya University Graduate School of Medicine)

Abstract

Pancreatic cancer is the fourth leading cause of cancer-related deaths in Japan. To identify risk loci, we perform a meta-analysis of three genome-wide association studies comprising 2,039 pancreatic cancer patients and 32,592 controls in the Japanese population. Here, we identify 3 (13q12.2, 13q22.1, and 16p12.3) genome-wide significant loci (P

Suggested Citation

  • Yingsong Lin & Masahiro Nakatochi & Yasuyuki Hosono & Hidemi Ito & Yoichiro Kamatani & Akihito Inoko & Hiromi Sakamoto & Fumie Kinoshita & Yumiko Kobayashi & Hiroshi Ishii & Masato Ozaka & Takashi Sas, 2020. "Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16711-w
    DOI: 10.1038/s41467-020-16711-w
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