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The lateralization of left hippocampal CA3 during the retrieval of spatial working memory

Author

Listed:
  • Da Song

    (Beijing Institute of Technology)

  • Deheng Wang

    (Shanghai University of Traditional Chinese Medicine)

  • Qinghu Yang

    (Beijing Institute of Technology)

  • Tianyi Yan

    (Beijing Institute of Technology)

  • Zhe Wang

    (Capital Medical University)

  • Yan Yan

    (Beijing Institute of Technology)

  • Juan Zhao

    (Beijing Institute of Technology)

  • Zhen Xie

    (Beijing Institute of Technology)

  • Yuchen Liu

    (Shanghai University of Traditional Chinese Medicine)

  • Zunji Ke

    (Shanghai University of Traditional Chinese Medicine)

  • Talal Jamil Qazi

    (Beijing Institute of Technology)

  • Yanhui Li

    (Beijing Institute of Technology)

  • Yili Wu

    (Jining Medical University)

  • Qing Shi

    (Beijing Institute of Technology)

  • Yiran Lang

    (Beijing Institute of Technology)

  • Heao Zhang

    (Beijing Institute of Technology)

  • Tao Huang

    (Beijing Institute of Technology)

  • Chunjian Wang

    (Beijing Institute of Technology)

  • Zhenzhen Quan

    (Beijing Institute of Technology)

  • Hong Qing

    (Beijing Institute of Technology)

Abstract

The hippocampal CA3 contributes to spatial working memory (SWM), but which stage of SWM the CA3 neurons act on and whether the lateralization of CA3 function occurs in SWM is also unknown. Here, we reveal increased neural activity in both sample and choice phases of SWM. Left CA3 (LCA3) neurons show higher sensitivity in the choice phase during the correct versus error trials compared with right CA3 (RCA3) neurons. LCA3 initiates firing prior to RCA3 in the choice phase. Optogenetic suppression of pyramidal neurons in LCA3 disrupts SWM only in the choice phase. Furthermore, we discover that parvalbumin (PV) neurons, rather than cholinergic neurons in the medial septum (DB were cholinergic neurons), can project directly to unilateral CA3. Selective suppression of PV neurons in the MS projecting to LCA3 impairs SWM. The findings suggest that MSPV-LCA3 projection plays a crucial role in manipulating the lateralization of LCA3 in the retrieval of SWM.

Suggested Citation

  • Da Song & Deheng Wang & Qinghu Yang & Tianyi Yan & Zhe Wang & Yan Yan & Juan Zhao & Zhen Xie & Yuchen Liu & Zunji Ke & Talal Jamil Qazi & Yanhui Li & Yili Wu & Qing Shi & Yiran Lang & Heao Zhang & Tao, 2020. "The lateralization of left hippocampal CA3 during the retrieval of spatial working memory," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16698-4
    DOI: 10.1038/s41467-020-16698-4
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    Cited by:

    1. Hefei Guan & Steven J. Middleton & Takafumi Inoue & Thomas J. McHugh, 2021. "Lateralization of CA1 assemblies in the absence of CA3 input," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    2. Thibault Cholvin & Marlene Bartos, 2022. "Hemisphere-specific spatial representation by hippocampal granule cells," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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