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NAP1-RELATED PROTEIN1 and 2 negatively regulate H2A.Z abundance in chromatin in Arabidopsis

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Listed:
  • Yafei Wang

    (State Key Laboratory of Crop Stress Biology for Arid Areas and College of Life Sciences, Northwest A&F University)

  • Zhenhui Zhong

    (University of California
    State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, College of Plant Protection, Fujian Agriculture and Forestry University)

  • Yaxin Zhang

    (Haixia Institute of Science and Technology, Fujian Agriculture and Forestry University)

  • Linhao Xu

    (Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), OT Gatersleben)

  • Suhua Feng

    (University of California)

  • Shima Rayatpisheh

    (David Geffen School of Medicine, University of California)

  • James A. Wohlschlegel

    (David Geffen School of Medicine, University of California)

  • Zonghua Wang

    (State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, College of Plant Protection, Fujian Agriculture and Forestry University)

  • Steven E. Jacobsen

    (University of California
    University of California)

  • Israel Ausin

    (State Key Laboratory of Crop Stress Biology for Arid Areas and College of Life Sciences, Northwest A&F University)

Abstract

In eukaryotes, DNA wraps around histones to form nucleosomes, which are compacted into chromatin. DNA-templated processes, including transcription, require chromatin disassembly and reassembly mediated by histone chaperones. Additionally, distinct histone variants can replace core histones to regulate chromatin structure and function. Although replacement of H2A with the evolutionarily conserved H2A.Z via the SWR1 histone chaperone complex has been extensively studied, in plants little is known about how a reduction of H2A.Z levels can be achieved. Here, we show that NRP proteins cause a decrease of H2A.Z-containing nucleosomes in Arabidopsis under standard growing conditions. nrp1-1 nrp2-2 double mutants show an over-accumulation of H2A.Z genome-wide, especially at heterochromatic regions normally H2A.Z-depleted in wild-type plants. Our work suggests that NRP proteins regulate gene expression by counteracting SWR1, thereby preventing excessive accumulation of H2A.Z.

Suggested Citation

  • Yafei Wang & Zhenhui Zhong & Yaxin Zhang & Linhao Xu & Suhua Feng & Shima Rayatpisheh & James A. Wohlschlegel & Zonghua Wang & Steven E. Jacobsen & Israel Ausin, 2020. "NAP1-RELATED PROTEIN1 and 2 negatively regulate H2A.Z abundance in chromatin in Arabidopsis," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16691-x
    DOI: 10.1038/s41467-020-16691-x
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    Cited by:

    1. Zhenhui Zhong & Yafei Wang & Ming Wang & Fan Yang & Quentin Angelo Thomas & Yan Xue & Yaxin Zhang & Wanlu Liu & Yasaman Jami-Alahmadi & Linhao Xu & Suhua Feng & Sebastian Marquardt & James A. Wohlschl, 2022. "Histone chaperone ASF1 mediates H3.3-H4 deposition in Arabidopsis," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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